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Chapter 89 Orphan Drugs

Facts have proved that this kind of man who is extremely cruel to himself is really very cruel from beginning to end. Although he has completed epidural anesthesia, it is still difficult to stop bleeding on a patient who is unconscious - the other party really does not cooperate with anesthesia.

The cystoscopy entered the bladder through the broken urethra that completed the hemostasis. Through the screen, Dr. Cao saw a ball of metal-shaped strips. Because of difficulty in urination, the patient's bladder was very full. Perhaps because of the long-term filling, the necklace became a large ball in the patient's bladder. It was absolutely impossible to pull it out directly, and it was physically impossible.

Dr. Cao sighed and began to operate the endoscope to play puzzle game - what is the relationship between this metal chain and the other end of the metal chain?

Time passed by bit by bit, epidural anesthesia is what people often call lumbar anesthesia. The anesthesia process has no effect on the patient's consciousness. The patient, whose mental condition has not been very stable, began to show some irritability. Fortunately, the nurses and Dr. Cao were constantly soothing. Although the patient was irritable, he was still able to lie in the bed without moving.

"It's almost done." In forty-eight minutes, Dr. Cao Xin finally untied the necklace that was formed and then slowly pulled it out of the patient's bladder.

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"Then you didn't even see the subsequent surgery, so you came to me to complain?" Sun Lien asked with a smile, "Duanli re-engagement is at least a third-level surgery, right? Isn't it good to watch it?"

"I gave it to my junior brother when I was a chance." Dr. Cao smiled, "Anyway, I did the cystoscopy, so it would be great to let my junior brother go on stage."

"I took a lot of patients today, but God blessed me, it's not very serious." Sun Lien sighed and pointed to the stack of outpatient certificates inserted on his desk. "The most serious thing is the lobular pneumonia I just mentioned to you, and I went to the respiratory department."

"Does there still be beds in the respiratory department?" When the doctors in the hospital chatted, the most common topic was whether there are beds in certain departments. "Respiratory diseases are at high risk in winter, can they still free up beds?"

Speaking of this issue, Sun Lien also felt a little tooth pain. "There is no place... I can only arrange the person to the observation room of the emergency room first." The respiratory department also felt that the patient needed to be admitted to the hospital for treatment. After all, although the patient is not old, he has a long history of smoking. Moreover, because the amount of rust and sputum is relatively large, the manifestation of cervical vein dilation can be observed.

Although it has not reached the point of respiratory distress syndrome, the situation cannot be underestimated. However, the respiratory department really cannot free up a bed - not to mention the ward, there is a patient lying on the bed in the treatment room. Extra beds are not allowed in the corridor of the inpatient department of medical units above the level of 2 to 2008. The patient must be diverted to the lower-level hospital as much as possible. But now none of these patients can meet the discharge standards. The new patient is on the emergency department number - the emergency department cannot refuse to receive treatment.

"Then you have to worry too much." Dr. Cao spread his hands and said helplessly, "It's the first-patient responsibility system. If this patient hasn't been transferred to the respiratory department for a day, you have to be responsible to the end."

After chatting for a while, Dr. Cao suddenly received a call.

"Ah?" He was stunned for a while, and suddenly stood up from his seat, "Have you contacted the pharmacy department?"

Sun Lien smelled something wrong from Dr. Cao's fierce movements. He also frowned and stood up.

"I understand, I'll ask immediately." Dr. Cao sighed, hung up the phone and started sending WeChat messages.

"Brother Cao, what's wrong?" Sun Lien asked curiously, "Is there anything you need help?"

"It's a fucking pussy..." Dr. Cao Xin, who has always been calm, cursed, "The patient who had the surgery has a malignant hyperthermia!"

Sun Lien looked confused, "What?"

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Malignant hyperthermia is a very serious hereditary disease. This is also the only serious disease among known diseases that can cause death by conventional anesthetic drugs.

As a subclinical disease, malignant hyperthermia will not have any signs or symptoms before onset. The skeletal muscle cell membrane calcium ion channel of these patients is defective. When exposed to volatile inhalation anesthetics or depolarized muscle relaxants, it can cause abnormal increase in the release of calcium ions. Only at this time can malignant hyperthermia suddenly erupt.

The skeletal muscles of the systemic malignant hyperthermia patients who are onset will begin to contract the whole body. The contraction of the systemic skeletal muscles will burst out with huge energy, which will prompt the patient's body temperature to rise rapidly without control and cause the patient to be in a high metabolic state.

The patient's body temperature will rise rapidly to around 45c to 46c, and hypercapnia will occur in a high metabolic state. At the same time, it will be accompanied by tachycardia, a sharp increase in blood pressure, a lot of sweating, increased blood potassium and other symptoms.

In other words, the body plans to burn itself to death.

The trouble is that general clinical cooling methods are difficult to have sufficient effect on malignant high fever, and the patient will eventually die due to organ failure.

Since it is an idiopathic disease in the department of anesthesia, Sun Lien basically has no idea about it. While Brother Cao sent a message to ask for help in the doctor exchange group of major hospitals, he quickly explained to Sun Lien what was going on now.

"The special medicine for treating malignant high fever is called Danqulorin." Cao Xin didn't even have time to wipe his sweat, and he was still typing quickly. "The problem is that not only do not have this medicine in our hospital, but also in the province's hospitals."

Danquolin is a special medicine for coping with malignant high fever. However, it has not been introduced, produced, or even batch numbers in China.

Even if you go through the green channel and purchase Danquolin from abroad, you can enter the country with a single drug approval and pass the test. The shelf life of Danquolin is only three years. It is useless to expire after the drug is successfully entered, which also leads to Danquolin having no reserve plan in domestic hospitals.

As for the road to imitation in China, it seems even longer and difficult. After all, there have been only 16 reports of malignant high fevers in 2015 to 2016. If a lot of money is invested in imitation, it may face the embarrassing situation where the cost cannot be recovered at all. As a company pursuing profits, pharmaceutical companies will certainly not touch this kind of hot yam.

Sun Lien thought about it and suddenly remembered that Takeda Pharmaceutical was preparing to acquire Shire Pharmaceutical - Isn't Shire Pharmaceutical a company specializing in the production of orphan drugs? Or... can you call Kobayashi Feng for help?

Without further ado, fight now.

However, Sun Lien didn't know that the two companies that could produce Danqulorine were both American companies.

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"President..." Kobayashi Tung's secretary quietly walked into the room and leaned against Kobayashi Tung's ear and whispered something. Kobayashi Tung is now sitting in the Charles Pharmaceutical conference room in Dublin, Ireland, where he is further negotiating the merger and acquisition transaction with senior negotiators of Charles Pharmaceutical. These damn Irish people don't know what they are in. They not only refuse to agree to the 64 billion US dollar merger and acquisition offer, but also want more things during their conversations - such as Takeda Pharmaceutical's board seat.

After all, Toyoko Kobayashi is a businessman who is used to storms, but a transaction can only be reached if both parties agree. If there is a trick between the two parties, the entire transaction may be completely ruined.

Kobayashi Feng was thinking about whether to throw Sun Lien out as a killer weapon now.

"Danquolin?" he asked his secretary with a frown, "Does our company have this medicine?"

"No." The secretary's voice was very low, "It is an orphan drug produced by American companies."

Kobayashi Tung thought for a moment, then suddenly said, "Pick the phone in, and let the translator come in."

The secretary turned around and left the conference room. Kobayashi Feng said to the vice president of Charles Pharmaceuticals opposite, "Mr. Aaron, I suggest that you pause the discussion first. A call for help from China called me. I want to ask you to listen with me."

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Chapter completed!
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