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Chapter 247 Wernicke's Encephalopathy

Wernik encephalopathy is a mental disorder caused by alcohol poisoning. It is a common metabolic encephalopathy in chronic alcohol poisoning. Patients with long-term drinking will experience symptoms of malnutrition, and the deficiency of thiamine caused by malnutrition will aggravate the patients' chronic alcohol poisoning.

Thiamine is vitamin B1. The main active form in the human body is thiamine pyrophospholipid (TTp), and TTp is an important cofactor in the reaction of the disease dehydrogenase complex (kgdhc) and the transketolase (Tk) of the pentose phosphate pathway. Cells need to convert glucose into the energy form aTp that cells can use. It can be said that this substance with a total content of only 30 mg in the human body is actually the basis for supporting the vitality of the entire human body. The lack of such an important cofactor will lead to brain energy metabolism disorders and at the same time lead to local lactic acid accumulation.

There is actually a more well-known name for nutritional diseases that lack vitamin B1 - beriberi. Beriberi was recorded in Zuo Zhuan in 314 BC and was described as "indulging in heavy legs" at that time. However, this disease has always troubled people for two thousand years. Especially in the 18th and 19th centuries, it was widely popular. At that time, in China, Japan, and Southeast Asia, about hundreds of thousands of people died of beriberi every year. It was not until 1926 that two Dutch chemists discovered and purified vitamin B1 from chaff that beriberi obtained the real "special medicine".

Because vitamin B1 cannot be synthesized by the body, and as a water-soluble vitamin, it cannot be stored in the body, it needs to be supplemented daily. Therefore, if the patient does not consume food containing vitamin B1 at all for 18 days, the patient will develop symptoms of vitamin B1 deficiency. After three weeks of deficiency, brain lesions will occur. If the patient has a long-term deficiency of vitamin B1, the patient will suffer from "bear foot disease".

"The main reason for Wernik's encephalopathy is that the patient lacks vitamin B1." Sun Lien's neurology is actually quite good, and he quickly got the point. "If Director Mei, you suspect that the patient has Wernik's encephalopathy, give her an intravenous supplement to vitamin B1. After replenishing quickly, you will know that you have to see if the patient's condition changes?"

"The patient and the patient's family must be informed before diagnostic treatment." Director Mei shook his head, "The child's parents died prematurely, and there are no immediate relatives, and..." She sighed, "She is not married yet."

"It means there is no agent who can make medical decisions for her?" Sun Lien frowned. This situation is the most troublesome and terrible. When you encounter such a thing alone, the doctors have no good idea to save people. "Then how did you do it these two days?"

Director Mei patted the bed, "If you can't treat diagnostically, you can only make sure of the diagnosis. But the hospital..." She suddenly stopped and looked around habitually. After confirming that no one was there, she was about to say something, but suddenly stopped. Director Mei paused for a few seconds, stared at Sun Lien with a strange look for a while, and suddenly asked, "I heard that your family bought this hospital?"

Sun Lien didn't expect Director Mei to say this, so he nodded without answering the conversation.

"That's great!" Unexpectedly, Director Mei grabbed Sun Lien's arm excitedly, "You should quickly let the imaging department turn on the magnetic resonance, and let the laboratory department open the machine immediately to check the vitamin B1 concentration in her blood."

After hearing this request, Sun Lien asked in surprise, "Did you do these tests?" He defaulted to thinking that Director Mei had already done these tests. The reason for not being diagnosed is that the indicators are normal. But now, following the words of his senior sister, she has not done relevant tests for the patient at all. She just made a diagnosis based on her own experience.

This is inappropriate, very inappropriate.

"There is no way... Our obstetrics and gynecology department has limited reception capabilities, and these contracted auxiliary departments have always ignored us..." Director Mei felt a little depressed when talking about this topic, "What's more, she has no family yet, and the cost of the inspection has not been settled."

Sun Lien frowned. In fact, with his current "identity", there is no problem to ask a certain department of the hospital to restart and provide corresponding services. The so-called "department contracting" is actually an illegal act defined by the Health Commission. It is not recognized and guaranteed from a legal basis, and it must be cleared out. In other words, the current paper mill hospital is completely the world of the Sun family.

But the actual difficulty in stopping the rich second-generation Sun Lien was the notice of closure and rectification when they came in the afternoon. According to the requirements of the closure and rectification of the paper mill hospitals were suspected of embezzling national social security funds and using unlicensed personnel for diagnosis and treatment activities. The illegal contracting department was ordered to suspend business and rectify for six months.

From the moment the notice of closure and rectification was issued, paper mill hospitals could no longer carry out any type of medical activities. Imaging department examinations and blood tests were also included in the scope of medical activities.

"The inspection fee is easy to deal with. It doesn't cost much for a check." Sun Lien now has money in his wallet and has confidence in speaking. "It really doesn't work, I can make it personally. But the problem is..." Sun Lien pointed helplessly outside the door, "The notice of closure and rectification has been posted, and now he can't do it even if he wants to do an inspection."

The two of them fell silent at the same time, and Director Mei seemed a little helpless. It was already difficult to be a doctor in this environment. Although I don’t know why Senior Sister Mei chose to be a doctor here all the time, Sun Lien still wanted to help her and the patient.

"About the diagnosis of Wernick's encephalopathy in this patient..." Sun Lien asked in a break in silence, "The main reason for your diagnosis is because she showed mental symptoms?"

"When she was sent here, she did have some mental problems." Director Mei replied mentally, "In addition, she also has symptoms of eye muscle paralysis - when she looked at me, the movements of her right eye were not in line with her left eye."

Sun Lien nodded. Ocular muscle paralysis and mental disorders appeared at the same time, which was indeed consistent with the symptoms of Wernik's encephalopathy. "It is indeed very likely that Wernik's encephalopathy." He was thinking about which hospital to transfer Liu Mei to.

"The most important thing is that my family lives quite close to hers," Director Mei added. "I have seen her several times during this period. Two of them, I saw her vomiting severely on the roadside."

This is the main reason for judging Wernick's encephalopathy. Sun Lien sighed. Severe morning sickness can indeed cause pregnant women to develop Wernick's encephalopathy - they can't eat and vomit, and they will definitely not keep up with the nutritional conditions. However, they are still so severe morning sickness at 26 weeks, which is somewhat inconsistent with what Sun Lien learned. Generally speaking, morning sickness is a type of early pregnancy reaction. In the early stage of pregnancy, due to the increase of hcg (chorionic gonadotropin), reduced gastric acid secretion and prolonged gastric emptying time, some pregnant women will experience severe vomiting. However, this reaction will generally weaken or even disappear after 12 weeks of pregnancy.

"Is there such severe morning sickness in 26 weeks?" Sun Lien asked with a frown, "She is so serious that she has Wernik's encephalopathy. Should she have a therapeutic miscarriage?"

After asking this, Sun Lien and Director Mei sighed together. Without family members or spouses, even if the doctors want to save Liu Mei by termination of pregnancy, no one can sign and they have no right to do so.

"I... I'd better call and ask." Sun Lien sighed and took out the phone from his pocket. "I don't know if the blockade in the Maternal and Child Health Hospital has been lifted. I hope I can accept the patient."
Chapter completed!
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