Chapter 295 The Theory of Contradiction
The guess of tumors is not groundless.
The evidence in imaging supports the tumor speculation, and Sun Lien also doesn't think Luo Ge will make mistakes in this issue. As an imaging physician with many years of work experience, he has seen countless malignant tumors. Moreover, being able to detect such hidden lesions itself shows that Luo Ge's experience level is still enough.
If Luo Ge’s guess is correct, then the status bar has no prompt...it seems to make sense - Tang Min’s main source of symptoms is severe stromal cell edema caused by insufficient AQP4 expression. All her symptoms are rooted in this congenital genetic disease, and before the tumor expands to a certain extent, the symptoms are hidden and can even be regarded as “asymptomatic”. Therefore, the status bar has no prompts and is completely overwhelming.
The status bar has no prompts and can be regarded as side evidence of tumor diagnosis. However, if cerebral ischemia is unreasonable, even if it is "asymptomatic cerebral infarction" or "quiescent cerebral infarction", it will not be completely asymptomatic. At least it will have symptoms such as dizziness, headache, limb numbness, and memory loss.
If symptoms appear, there will definitely be relevant prompts in the status bar - as for whether to give the name of the disease or give a sufficient diagnosis, this is not necessarily the case.
Then, the next problem to be solved is relatively simple. Sun Lien continued to say after a while, "We need to understand what type of tumor this is and why the tumor suddenly disappears."
"If it's a tumor, I have an idea." Yuan Ping'an injected, "From the area of the disease, it's more likely that this tumor is glioblastoma, right?"
Luo Ge nodded, "Several locations where the disease occurs are in the white matter of the brain, away from blood vessels and glands - the most likely ones in these locations are indeed glioblastoma."
"Tang Min's AQP4 expression is insufficient, and it also affects her glial cells." Yuan Ping'an frowned, "I remember when I checked the information before, I saw that AQP4 expression is closely related to brain glioma..."
"A positive or negative relationship?" Zhou Ce asked, "She now has insufficient expression of AQP4 protein. We have temporarily improved her hydrocephalus through drug effects. If it is a negative impact...will the treatment must be stopped later?"
This is a hypothesis that makes people sweat behind their backs. If the efficiency of AQP4 protein increases, which will lead to gliozoite tumors, doctors will have to reevaluate the treatment plan for Tang Min. The family also needs to choose one of the two cruel options: "Cancer" and "Diet Hydrocephalus".
"Not necessarily...what if the cancer is primary?" Xu Yourong had a different opinion on this. "If there is a negative impact, how can we explain that the placeholding lesions disappear on their own? The area of each lesion is not small, but before they become solid tumors, the placeholding is absorbed. These placeholdings are not the size that the immune system can handle on its own."
"So..." Sun Lien concluded, "What factors prevented or curbed the development of tumors in her skull? And this factor seems to be related to AQP4 at the moment?"
The conference room fell silent, and everyone was thinking about Sun Lien's speculation. Soon, they discovered that, judging from logic or the traits shown by the disease itself, this speculation is indeed possible.
"I'll improve the paper statistics in this regard." Yuan Ping'an volunteered, "If you look for the previous browsing records, you should have results soon."
"I suggest increasing the observation frequency. Anyway, the MRI downstairs are also placed." Luo Ge suggested, "The frequency is increased again to once a day. If necessary, you can consider going to the outer hospital for PET. If it is really a tumor, you also need to start intervention as soon as possible. Tumors appear in multiple areas of the same organ, which is close to the third stage."
Cancer cells are very unstable abnormal cells, and their abnormalities are also manifested in their ease of falling off. Most normal human cells are closely connected with other cells and play their due roles. Cancer cells lack this characteristic - they are very likely to fall off from existing cancer cell clusters, and then follow blood or lymph to other places in the same organ, or enter other organs. This is the metastasis of cancer.
"If you look at it from this perspective alone... it really doesn't look like cancer." Bruen muttered, "The tumor itself is not big, and it is absorbed without forming a complete solid placeholding. But there is also extensive intra-organ metastasis... These two symptoms, as the grading of cancer, are completely contradictory."
Dr. Pascal continued, "Anyway, Dr. Sun has met many strange patients. Even if he meets a patient with innate immune cancer, I don't think it is too strange." He turned to Sun Lien and said, "Let's improve the biochemical examination together, and check markers such as TSGF and CD133."
Sun Lien nodded, turned around and began to make doctor's instructions. The other doctors continued to discuss in a low voice.
"What you said just now gave me some inspiration." Yuan Ping'an moved his butt and sat down next to Dr. Pascal and said, "Is it possible for something like immune cancer?"
"As long as it is a multicellular organism, it is impossible." Dr. Pascal rolled his eyes. "Multicellular organisms need to divide cells to maintain tissue activity. Gene replication errors are inevitable, so the immune system will attack the wrong cells to prevent cancer... This is the content in the textbook." He said seriously. "The strength of the immune system can prevent cancer from occurring to a certain extent, and the best counterexample is the previous case report of "transmitting cancer across species."
"The HIV-positive patient was diagnosed with cancer. Immunohistochemistry reported that these cancer cells were from roundworms, right?" Yuan Ping'an nodded, "I've seen it." He thought for a while and asked, "Since cancer is not immune, what can prevent the reproduction of cancer cells that have already spread?"
"Where do I know to go? I'm not an expert in cancer." Dr. Pascal called Xu Yourong, who was sitting beside him, "Your wife is a cancer expert. What do you think?"
"I know much about cancer." Xu Yourong replied very naturally, "In the past, after brain tumor resection, we would basically hand the patients directly to the oncology department for treatment. They also came up with relevant chemotherapy plans."
The topic returned to the starting point, Yuan Ping'an shook his head, "Forget it, I'd better go and read the literature." He stood up and stretched, "I thought Tang Min's case was basically over..."
"Team leader Sun has spoken. Why don't you hurry up and go and read the documents?" Zhou Ce smiled, "Maybe this is a great discovery at the Nobel Prize level."
Chapter completed!