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Chapter 486 Comparison of Two Control Groups

Chen Xia has the best speaking language, and he mainly asks about medical history.

Zheng Haisheng has the best English handwriting ability and has given him all medical records.

After all, Chen Chun is a doctor from the First Provincial Hospital, and she is young and has good eyesight and strong hands-on ability, so she is the leader of the gastroscopy.

Xuan Yongda has kept all the methods and precautions for use of all drugs in mind, and he is the "captain" and is more responsible, so all the treatment drugs are kept by him and handed over to the nurses for the patients.

Everyone has a clear division of labor and the assembly line operation is in an orderly and orderly manner, allowing doctors from all over the country who are observing on the side and supervisors of the International Digestive Diseases Commission to nod in their hearts.

This four-person team won everyone's respect with their professionalism, especially in China, where China is still a backward country. These doctors have to engage in clinical work, conduct research, and learn English.

This is really not easy, he is really a role model in the medical field.

Later, there was a global study that found that 50% of people around the world had been infected with Helicobacter pylori or were infected.

So even if there are differences in races and national conditions, the infection rate of Helicobacter pylori in the English population is also very high, which is only in the general population.

When we go to the gastroenterology department, patients who come to the hospital come to the hospital with stomach pain as the main complaint. So there is no need to think about the positive rate of Helicobacter pylori in such a group of people, it must be even higher.

Chen Chun and Xuan Yongda were still worried, fearing that England would have a separate meal system, would the positivity rate be very low? That would have been slapped in the face on the spot.

Chen Xia was not worried at all. Oral-oral transmission, family meals or KISS were just one of the reasons, but not the only reasons. Others such as:

Fecal-oral transmission: If the gastric mucosa falls off, Helicobacter pylori will fall off and will be excreted with feces, contaminating water and food, and then spreading to other people.

Gastric-oral transmission: If Helicobacter pylori is infected, it will also exist in gastric juice. Therefore, when the infected person vomits, the bacteria present in the vomit will be transmitted to others, especially during the acute infection period, which is more likely to be transmitted to others through vomit.

Imoral transmission: People infected with Helicobacter pylori will leave bacteria on the gastroscopy during gastroscopy. If the gastroscopy is not cleaned thoroughly, it may be transmitted to other people.

The simplest example is that in China, these Tibetans' diets are mainly tsampa, butter tea, dairy products, and hand-catch meat. They are typical separate meals, and everyone eats their own food.

However, the Tibetan Helicobacter pylori infection rate is the highest in the country, as high as 82%, so the co-ed meal system is definitely not the main transmission route of Helicobacter pylori.

Even from a global perspective, the infection rate of Helicobacter pylori in China is not the highest. The highest is the starving black African uncles who have nothing to eat.

For example, in Nigeria, the infection rate among the general population is 90%, the world's number one, and they are also made in separate meals.

The camera returns to the inpatient department of the Gastroenterology Department of Wellington Hospital.

On the first day, all 20 beds were filled. After the gastroscopy was checked the next day, tissue specimens were extracted. The feedback from the pathology room was quick. When all the results were placed in front of everyone, everyone took a deep breath and the infection rate was 85%.

Chen Chun and Xuan Yongda quietly breathed a sigh of relief. The infection rate data is not much different from that in China.

This data is also the first official Helicobacter pylori infection rate data in foreign countries. This made some doctors observing next to me mutter in their hearts, is Helicobacter pylori really the main cause of stomach disease?

But some doctors deny themselves in their hearts. So what if they test positive? How do you prove that Helicobacter pylori is a pathogenic bacteria?

It's like catching a thief. There is a bad guy in the crowd, but if you don't have any evidence, is he the case?

All patients were reviewed by the International Committee on Digestive Diseases, including their current clinical symptoms and test reports of positive Helicobacter pylori, and they were all recorded, which was related to the evaluation of treatment.

Clinical evaluation is to see if the patient still has clinical symptoms such as stomach discomfort after treatment with quadruple therapy.

Laboratory evaluation is to see if Helicobacter pylori can still be detected after 2 weeks?

At the same time, in order to ensure the fairness and rationality of the experiment, Wellington Hospital tried every means and transferred some patients from other hospitals to serve as a control group.

There were also 20 patients. Two control groups were treated together, one group used quadruple therapy and the other group used traditional symptomatic treatment methods. Then evaluate which group had better treatment effect.

At this point, Chen Chun's self-confidence came back. Treatment? How could treatment be defeated?

Since foreign countries have a very low acceptance of traditional Chinese medicine and is not recognized by the mainstream medical community, it can be said that it cannot be ranked in the elegant hall.

So for the sake of the smoothness of the experiment and for doctors from all over the world to better accept it, Chen Xia did not come up with the "Sanliuweitai" this time, but took out the omeprazole capsules.

The so-called quadruple therapy is omeprazole + bismuth potassium citrate + amoxicillin + clarithromycin.

Except for amoxicillin, an existing drug, all three other drugs are first-class and have all applied for patents.

The introduction of drugs is also the highlight of this clinical experiment. As the inventor of the drug, Zheng Haisheng specially introduced the pharmacology and related laboratory data of these three drugs to everyone.

"Clarithromycin uses erythromycin as the raw material to remove a methyl group on the amino group, and then react with benzyl chloroformate to protect the hydroxyl group and amino group on the tetrahydropyran ring on the side chain of the 5-position.

Then, methane iodide is neutralized in dimethylsulfoxide and tetrahydrofuran, methylation of the hydroxyl group at the 6th position, catalyzed hydrogen to remove the protective group, and the formaldehyde reaction to hydroxymethylation of the amino group, and finally reduced to methyl."

Professor Gregory interrupted and asked: "In other words, clarithromycin is also a macrocyclic lipid, which is an upgraded version of erythromycin, right?"

Zheng Haisheng nodded: "Teacher's understanding is completely correct, so clarithromycin can not only treat stomach problems, but also its antibacterial spectrum is the same as erythromycin and can be widely used in clinical practice. At the same time, if patients with clarithromycin are allergic to clarithromycin, they can be replaced by tetracycline."

The doctor at the scene was taught another lesson.

An antibiotic, an acid-suppressing drug, and a bismuth agent were all invented by Chinese doctors, which surprised everyone. Moreover, the introduction and instructions for related drugs are all formal, and all patents have been applied for, so there is no doubt about the authenticity.

When did China's medical and pharmacy have become so powerful?
Chapter completed!
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