After returning to the institute, Zhou Yang pondered for a moment and then wrote about the situation of the second-generation hepatitis B vaccine.

No one understands the dangers of hepatitis B better than Zhou Yang!

Compared with the actual situation, what Yang Chunhua and Duan Yinzhong said at the meeting just now is just superficial.

In a previous life, the country launched an extremely important investigation into this terrible infectious disease in 1992. The investigation lasted for three years and was the largest seroprevalence investigation of hepatitis B across the entire population since the founding of the People's Republic of China.

The results of this survey showed that the prevalence rate of hepatitis B virus carriers in the country was as high as 9.75%. According to population estimates at that time, the number of hepatitis B virus carriers in my country was 120 million (there are currently more than 70 million hepatitis B virus carriers).

The results of this investigation were like a bomb that suddenly detonated without anyone paying attention. In panic, rumors spread.

The impact is so great and the harm is so profound that no disease can be compared with this disease!

More importantly, although hepatitis B is a very harmful disease, there is still no cure.

The only way is to develop a vaccine and prevent and treat it in advance!

Therefore, after the establishment of this medical research center, Zhou Yang was determined to research a hepatitis B vaccine.

After all, for an infectious disease like hepatitis B, the vaccine is almost a salvation.

Of course, more importantly, once vaccine research is successful, the economic benefits that can be created are also very considerable.

The world's first hepatitis B vaccine was successfully developed in Thieving Eagle in the 1970s. However, due to many reasons such as technology and cost, this vaccine has not been popularized on a large scale. It only carries out immunization programs for high-risk groups.

The hepatitis B vaccine that has been commercially promoted on a large scale is Merck's second-generation vaccine. This vaccine was launched in 1986. Since then, the incidence of acute hepatitis B in China has dropped by 80%.

The results are naturally gratifying, but the price is also unaffordable for ordinary people!

At that time, the price of hepatitis B vaccine in China was US$100, which would be equivalent to half a year's income of an average family in China.

Therefore, as long as the second-generation hepatitis B vaccine is successfully developed, it will almost be equivalent to creating a money printing machine that will not stop.

At that time, only through Weiyuan Company controlled by Yan Gengdong, this vaccine can be sold all over the world, and its income will definitely not be worse than atorvastatin for treating chronic diseases and fluoxetine, a specific drug for depression.

Let’s not talk about making money. If we have a cheap and safe hepatitis B vaccine, given the importance our country attaches to the people, this vaccine will inevitably be promoted and popularized on a large scale. How many lives can be saved by then?

family.

Perhaps, if hepatitis B vaccination is given to newborns on a large scale from now on, the number of hepatitis B patients in our country may not reach the peak of 120 million.

Therefore, it is imperative to study the second generation hepatitis B vaccine.

It's just that Zhou Yang is not particularly confident about this vaccine. The reason is simple. This is not his area of ​​expertise.

Not only is Zhou Yang not good at this, but no one in China is good at this either, because compared to the first generation plasma-derived vaccine, the second generation recombinant rdna hepatitis B vaccine is a genetically engineered vaccine.

Fortunately, Zhou Yang had learned about the process of this genetically engineered vaccine in his previous life, and knew that its core was made using yeast engineering bacteria as a carrier, that is, the surface antigen of the hepatitis B virus expressed by recombinant Saccharomyces cerevisiae was purified and added with aluminum hydroxide adjuvant.

Just knowing these things is not enough, and it may not be possible to develop a safe and reliable vaccine.

The reason is also simple. There are too many things that need to be controlled in the process of vaccine development. If there is a problem in one link, all efforts will be wasted.

This is just like smokeless gunpowder. We all know that its main ingredient is black powder, and the classic black powder formula is monosulfide, dinitrate, and charcoal.

But if you actually have all these raw materials in front of you, can you make smokeless gunpowder?

What's more, our domestic genetic engineering has just started, and there is a big gap with foreign countries in terms of talent reserves and technical equipment.

Therefore, Zhou Yang originally considered the second-generation hepatitis B vaccine as the third key product of Yan Gengdong's sickle plan, but after thinking about it for a while, he always felt that it was not suitable.

After all, he is not sure whether a second-generation hepatitis B vaccine will definitely be developed, nor is he sure how long the development cycle will be.

Therefore, this can only be considered a required item.

It’s good to study first. It’s good to have results. If you don’t get results in a short time, it won’t have much impact!

As for the third product of the Sickle Project, Zhou Yang has already thought about it, which is the famous little blue pill.

Although it is a bit wasteful to take out this kind of killer weapon at this time, after all, the patent protection period of medicines is only 20 years. After the patent expires, it will be made public and become a patent that can be used by the public society, and the patent will contribute to the entire society.

In other words, if the little blue pill is taken out now, it will become a public patent in almost 1997, which is somewhat of a pity.

However, in comparison, we are now even more short of money and foreign exchange!

Maybe by that time, we no longer need to obtain funds through this method.

Therefore, after some thinking, Zhou Yang decided to take out this big killer weapon and let Yan Gengdong and the others quickly harvest the whole world.

He just asked Song Shi to contact Li Linzhang just to ask him to come back and take charge of this project.

In fact, compared with the second-generation hepatitis B vaccine, the difficulty of developing the little blue pill is almost negligible. As long as Zhou Yang explains the basic steps, with the scientific research capabilities of Li Linzhang and others, it can be developed very quickly.

It's just that Zhou Yang doesn't have time to do it himself now, so he can only let Li Linzhang be the "father of Brother Wei"!

I hope Professor Li will not cause trouble for him in the future...

........

Zhou Yang spent the whole morning working on these things in the office!

However, just as he was about to get off work, a familiar voice suddenly sounded outside the door: "Report!"

"Come in!"

With Zhou Yang's permission, the door of the office was pushed open, and then Fan Debiao was seen walking in from the outside.

Seeing the sweat stains on this guy's tanned skin, Zhou Yang smiled and asked: "Why is he sweating profusely again? What were you doing at noon?"

"It's nothing. At the request of that boy Yun Changjie, I took them to Huangshi Cliff to test the equipment!" Fan Debiao said.

"Why are you testing again? Didn't you just test it two days ago?" Zhou Yang frowned.

"Yes, we tested 7 units the day before yesterday and 18 more units today!"

Then Fan Derbiao said helplessly: "That guy is the Axis. What I mean is that all the radars are like a ball. Just randomly check and test them. The same is true for other units. But he just can't do it. He has to test every one.

!”

"He can take the test if he wants. Why do you have to follow him every time?" Zhou Yang asked in confusion.

"They are all a bunch of new recruits, and the test requires the use of live ammunition. I am worried that they will have an accident, so I can only follow them and watch!" Fan Derbiao said.

Zhou Yang looked at him up and down. When he saw this guy's oily hands, he immediately said: "I think your hands are itchy and you want to play with cannons!"

Seeing that his idea was exposed by Zhou Yang, Fan Debiao didn't feel embarrassed at all, and immediately said with a smile: "Well...this is not idleness, but also idleness..."

"Don't fight haha, how many shells have been consumed today?"

"6 mortar shells, 22 howitzer shells!"

"We only pick the expensive ones. You should take it easy. Our unit is not a front-line combat unit, but we don't have that much ammunition rationing. It's hard to apply for it if it's all gone!"

"Hahaha, if it's really gone, just ask your boy Yun Changjie and ask him to apply to the higher authorities. Who told him to insist on testing each device one by one!"

"You did a good job of dumping the blame!"

Then Zhou Yang said again: "But if you are really energetic, don't throw all your anger at the cannon!"

"Uh...what do you mean? Where else can I spread it?"

"Go to Uzhina. Do you know that Yunlong's wife is pregnant?"

"Really or not, that boy is going to be a father?"

"Yeah, so you have to work hard. When the cannon hits your wife, don't keep thinking about the few shells in Huo Huo's arsenal!" Zhou Yang said.

"Understood!"

Seeing that Fan Debiao seemed to be about to turn around and leave, Zhou Yang immediately asked: "You came here just to tell me this, right?"

"No, with all your fuss, I almost forgot about the real thing!"

"What's the matter?"

"The matter with the kid named Gao's family has been settled. His father and mother are back!" Fan Debiao said.

After hearing this, Zhou Yang immediately cheered up!

........
Chapter completed!