"Sir, the equipment use application you submitted on Wednesday was rejected. I am very sorry. Please make an appointment for the next use time in time."

Although the content of the words seemed to express an apology, the cold voice on the other end of the phone showed that the person who spoke was really not sincere at all. This made Tian Lu feel angry and had to sigh helplessly and slump.

He sat back on the chair.

He thought of some things too simply.

There are thousands of researchers at Scripps Research Institute, more than 200 professors, and dozens of research groups of various sizes. The number of experiments conducted every day is naturally mind-numbing, but he did not

What comes to mind is that in just one month, applications for the use of equipment were rejected three times. Without exception, they all conflicted with the plans of other researchers.

This week's appointments were already fully booked, and they would have to wait until next week at the earliest, so Tian Lu's experiment had to be stopped helplessly.

The experiment he is doing now is only the initial stage of the two-year plan, but even in this initial stage, he has been stuck here for three full months!

The first two months after arriving at Scripps Research Institute were training on basic experimental skills, how to use various instruments, etc. Although Tian Lu mastered these skills early with the help of system simulation implementation functions,

He still had no choice but to accept the institute's arrangement. After all, there was no record on his resume indicating that he had received similar training.

In the third month, after he officially started his experiment, he encountered unexpected situations one after another that he had never imagined. The rejection of the application for the use of the instrument was just one of them.

Once or twice is a coincidence. If it happens a third time, it may be your own problem.

It was almost time to get off work. Now that the results had been confirmed, Tian Lu had no energy left, so he packed up hastily and walked out of the laboratory.

There are thousands of people in the research institute. Even if there are more people working overtime to do experiments, there are still many people who get off work on time. Amid the bustling crowd, Tian Lu took out his bicycle, put on his helmet, and drove out of the gate of the research institute.

Among the many people who are getting off work, the bicycles on Tianlu are not conspicuous. In fact, many researchers use bicycles to commute to work every day, not because of environmental protection, but mainly for the purpose of exercise. Scientific researchers are busy at work, and many

Sometimes we often spend several days in the laboratory for an experimental result, so many people use cycling to and from work to exercise, killing two birds with one stone.

It takes about fifty minutes to ride a bicycle from the research institute to Tian Lu's rented house. Tian Lu also uses this method to strengthen his body.

On the slightly empty road, Tian Lu analyzed it carefully in his mind while riding.

The first step of his experiment was to target pericytes.

Tian Lu's long-term goal is the mechanism of action of the blood-brain barrier, but this is a complex and huge subject. In order to fully explain the complete system of the blood-brain barrier, there is too much work that needs to be done in advance. He can only take one step.

Come one step at a time.

The main structure of the blood-brain barrier is brain capillary endothelial cells. The endothelial cells are also surrounded by a continuous basement membrane. Beyond the basement membrane, there are many perivascular astrocytes that cover about 85% of brain capillaries.

Surrounded by the surface. This forms a multi-layered membrane structure of brain capillaries, which constitutes a protective barrier for brain tissue. Pericytes are adjacent to astrocytes and have extremely complex cell regulatory functions. In reality, they have

The discovered functions include regulating blood flow, promoting angiogenesis, migration to endothelial cells, phagocytosis and antigen presentation, as well as stem cell function, etc.

Among the cells that make up brain capillaries, endothelial cells mainly form tight junctions and are responsible for mediating permeability and signal transduction, while pericytes exchange ions and small molecule substances with endothelial cells through gap junctions. Plasma cell processes are formed in a peg-socker manner.

Contact with the basement membrane and with astrocytes and peripheral blood vessels. It can communicate with endothelial cells and other cells of the neurovascular unit (neurons, astrocytes, etc.) by means of direct contact and through autocrine and paracrine signaling molecules

) for information contact.

In reality, although some discoveries have been made about the role of pericytes on the blood-brain barrier, they are not systematic or accurate. The first step in Tian Lu's research is to accurately and completely explain the mechanism and specific content of pericytes. And the experiment

The first step is to determine the molecular markers used to screen and identify pericytes. Currently, commonly used ones include a-**a, 3g5, ng2, etc., which are all cell surface proteins, but the specificity needs to be further confirmed. Tian Lu now

The purpose is to determine a molecular marker as a basis for subsequent experiments.

In the medical literature support system, the study four years later had already elaborated on the experimental process and results in great detail. All Tian Lu had to do was to reproduce it.

But even this simple reappearance has been interrupted several times!

"There must be something wrong with my arrangements!"

Tian Lu thought secretly.

It is true that sometimes instrument reservations may be cancelled, because priority must be given to the experiments of certain experts, but in most cases, fairness can still be guaranteed. Especially Tian Lu’s current experiments, which require

It's just some conventional equipment, not very high-end, so if it was rejected three times, I'm afraid there is really a problem with the time arrangement.

Generally speaking, Tianlu makes reservations three days in advance, but judging from the current situation, I'm afraid it needs to be made at least a week in advance!

For the entire research content of the blood-brain barrier, the scientific research support system has provided a complete plan and extremely detailed process, but the specific trial schedule and other content still need to be handled by the researchers themselves.

In a sense, these two years at the institute were a bump in the road.

Just like the application of system functions in clinical practice, the application of scientific research support systems in reality also requires Tian Lu to become familiar with and master it through practice.

In the early days of research, Tian Lu was just one person, and the most important thing was the experimental process. However, during this period, he had to encounter many problems that were impossible in systematic experiments. For example, the application for experimental raw materials, the application for experimental equipment,

Arrangement of experimental progress, reports to superiors, etc...

If Tian Lu has made certain results and sees bright prospects, the institute will inevitably increase its investment. If there are technicians or even researchers involved by then, then as the leader, he will have to do more.

Yes! For example, arranging the work of personnel, coordinating the work of each group, controlling the progress of all work, etc...

There is no doubt that the scientific research plan given by the system is systematic and well-organized, but precisely because it is too systematic, Tian Lu is destined to be unable to continue on his own.

In fact, any important research result in the medical field is the accumulation of years of results of countless scientific researchers!

Just like the research on the mechanism of the blood-brain barrier, although it will be fully elaborated in the future, it relies on hundreds of years of accumulation and precipitation!

From the discovery at the beginning of the 20th century to the complete elucidation of its mechanism twenty years later, it took more than a hundred years for countless scientific researchers, countless research institutions, and even countless funds to invest in it, and finally formed a complete set of

theory!

Although Tian Lu had foresight and was able to use the simplest and most direct method to reach the end point, this linear process is still not something that can be completed by one person or even a small team.

“There is so much to learn!”

Tian Lu secretly sighed. Whether as a doctor or a scientific researcher, with the help of the system, he can stand on the top of the world in the shortest time, but if he wants to transform the knowledge of the system into results in the real world,

He must get something more in reality!

It requires huge resources, effective management, and enough support...

These are things you can’t get in the system!

"Produce phased results as quickly as possible, and then apply to form a small team! Then, learn how to manage a scientific research group, or even go further, learn how to manage a research project...

..”

Tian Lu smiled bitterly and shook his head, thinking secretly.

If possible, Tian Lu really just wants to be a pure technician. Even in the future, he also hopes to position himself as an academic leader and just control the content of the research. Only in this way can he avoid too much dispersion.

Attention, so as to maximize the role of the system and produce the results you want as quickly as possible.

But of course it's impossible in reality.

To put it bluntly, the strength is still not enough!

If he has enough significant results to publish, and if his research can make people see bright prospects, then naturally countless companies or research institutions will take the initiative to pounce on them and provide sufficient resource support. When the time comes, he can

Form your own research team, hire experienced project managers, and even get a large number of scientific research equipment at your disposal...

All of this must have a premise: Tian Lu must come up with exciting research results!

"Boost!"

Tian Lu saw the apartment building he rented in the distance, lowered his head suddenly, leaned down, and the pedals of the bicycle spun rapidly like a hot wheel...
Chapter completed!