A Nobel Prize winner once claimed: "The 20th century is the century of genes, and the 21st century is the century of the brain."

The breakthrough achievements of molecular biology in the late 20th century brought about tremendous changes in the position of life sciences in the natural sciences, and the Human Genome Project is also considered one of the three greatest human science projects in the 20th century!

In the 1990s, the world's major scientific and technological powers accelerated their investment in neurobiology research, such as the "Ten-Year Brain Plan" proposed by the United States, the "EC Brain Ten-Year Plan" in Europe, and Japan

The 'Brain Science Era Plan', a large-scale cross-century research plan, plans to invest huge amounts of research funds in the next ten or twenty years to focus on neurobiological research.

Of course, even if it is supported by the actual actions of various countries, this sentence must still be a bit exaggerated. However, in any case, there is definitely no problem: the 21st century is the century of life sciences!

This is most obviously reflected in the top scientific and technological journals.

I don’t know since when, when people discuss top scientific journals, they often use nsc or cns instead, which refers to the three books "nature", "science" and "cell"

It seems that as long as a paper can be published in these three top magazines, it must be good research.

"Cell" is a purely life science journal, and although "Nature" and "Science" are comprehensive journals, life science articles account for a very large proportion. It can be seen that the world attaches great importance to life science.

To what extent.

Of course, being able to publish an article in three top journals is also the dream of all life science researchers in the world, especially those countries outside of the major scientific research countries. Once a researcher can publish an article in three magazines,

It often becomes their lifelong capital...

In September 2011 and March 2012, less than half a year before and after, articles from two research institutions were published in the magazine "Nature Neuroscience". The content of the articles was surprisingly consistent, both about medical problems that have existed for a century:

Research on how to break through the blood-brain barrier.

For a time, these two studies seemed to be the same, but they were very different. They caused a huge sensation in the world of neurobiology and even in many fields of life sciences!

The first article published by "nature" comes from the Department of Immunology of Cornell University in the United States. Scientists there use a molecule in mice, the adenine nucleoside receptor, to control the entry of large molecules into the brain. When adenine nucleoside

When the receptor is activated on the cells that make up the blood-brain barrier, a channel is established into the blood-brain barrier. In the experiment, they successfully transported large molecules the size of dextran and antibodies into the brain, trying to

to clarify where they could allow large molecules to reach and whether the method had size requirements. They also succeeded in getting an amyloid-beta peptide antibody to cross the blood-brain barrier of genetically modified mice and observed it attaching to the protein that causes the disease in the mice.

Amyloid plaques in Alzheimer's disease.

The article published later was also from the United States and was completed by the Department of Neurobiology at the famous Splix Institute.

In this article, signed by "Tian Lu" as the first author, the researchers also claimed that they successfully broke through the blood-brain barrier. However, unlike the Cornell University study, the results of the Splix Institute's study were more clear.

It is also more systematic.

Strictly speaking, the research results of Splix Institute are not one article, but a series of three articles! In the current issue of "Pericyte Autocrine Signaling in Pericyte/Endothelial Cell Co-culture System"

"Molecular Effects on Endothelial Cells", first briefly introduces the content of this series of articles, including the results of successfully breaking through the blood-brain barrier, and at the end of the article, it previews the titles of this series of articles in the next issue of the magazine:

"Study on the role of endothelial cells in the defense mechanism of the blood-brain barrier"!

Unlike Cornell University's research, which only achieved the result of breaking through the blood-brain barrier, the scientists at the Splix Institute seemed to want to first try to elucidate part of the mechanism of the blood-brain barrier before talking about specific breakthroughs.

Specific methods of the blood-brain barrier. In the preview of this issue, in the last article, researchers from the Splix Institute even listed a list of substances they have tested that can successfully pass through the blood-brain barrier!

The preview of this article not only made scientists around the world full of expectations in this field, but also the multinational pharmaceutical companies were extremely excited. Many interested people could not wait for the publication of the next two issues of the magazine and got on the plane one after another.

Flying to San Diego, California, USA...

.................................................................

..

Meanwhile, on the edge of California's Sonoran Desert.

"call......"

Tian Lu took a deep breath, tilted his body, and with a bang, his huge luggage fell to the ground, and he himself sat down on the soft yellow sand.

"So tired!"

Leaning on his backpack, Tian Lu gasped rapidly. He felt as if his whole body was falling apart. The location of his backpack was also in burning pain. He must have been torn by the heavy luggage.

Seeing Tian Lu's appearance, Ye Lan quickly took out a water bottle from his bag and handed it over: "Let's drink some water first."

Gudong, gudong, he raised his neck and drank several large gulps. The fire in his chest was extinguished a little. Tian Lu looked at the endless yellow sand in front of him, suddenly shook his head, and said with a wry smile: "What exactly is Brother Lei recommending?"

Place? What else can you say is so majestic that it makes people feel happy to see it! It just looks like a piece of yellow sand. Besides sand, what else is there to see?"

"I think it's quite pretty."

Ye Lan took the kettle from Tian Lu's hand and drank a few sips himself before saying with a smile: "Although I can't understand the artistic conception that Senior Brother Lei mentioned, I have always been very interested in the scenery I have never seen before.

Tolerance."

Tian Lu curled his lips and said nothing.

The location where the two of them were was just on the edge of the desert, but in Tian Lu's heart, he had already made up his mind and would never take a step further inside! Let's not talk about whether there is any danger in the desert. As far as the scenery is concerned, it is boring.

It’s tawny, what’s there to see?

"Jingle Bell......"

During the break, the cell phone in the small bag beside Tian Lu suddenly rang. In this empty desert, the high-pitched ringtone was unusually harsh. Tian Lu couldn't help but grab the cell phone and quickly pressed the answer button.

"Hello, I'm Tian Lu."

...

"Oh, it's Lele...Yes, I'm on vacation for a month. Didn't I just come out! After so many years in the United States, I haven't taken Lan Lan out to play!"

...

"Ah? You know everything?...Haha, thank you!"

...

"Okay, let's talk later. Goodbye!"

After saying the last sentence, he threw the phone back into the small bag with a bang. Tian Lu leaned back heavily on the backpack and kicked his legs vigorously. After walking all morning, he could sit down and rest.

Resting his feet made him feel particularly comfortable.

"Why is Lele looking for you?"

Ye Lan fiddled with the pebbles at hand and asked intentionally or unintentionally.

"What else can you do?"

Tian Lu stretched, yawned and said, "Have you heard about my publication? Please call me to congratulate me! By the way, did you tell her?"

Ye Lan smiled, leaned into Tian Lu's arms, and said coquettishly: "Didn't I let it slip when I called her last night? Besides, it's not a bad thing, why should I hide it from her?

?”

"hehe."

Caressing Ye Lan's hair, Tian Lu had no choice but to laugh at his little thoughts. But after just smiling, his brows immediately wrinkled again, and he said with a grimace: "I think this place is really cool."

There’s nothing interesting. Anyway, there are quite a few scenic spots listed by Lei Kang. Let’s go to the next place!”

"All right."

Seeing that Tianlu really had no love for this place, Ye Lan nodded indifferently. She was just curious about the scenery of the desert in front of her. She had no special feelings, and she was not very nostalgic.

only......

"Is it really okay for you to take a month's leave? Over there at the research institute..." Ye Lan asked worriedly.

"What is the problem?"

Tian Lu played with a small strand of Ye Lan's hair with his fingers and said lightly: "I have worked hard for more than a year, and now I am just taking a one-month vacation. Who can say anything?"

After working hard for more than a year, with the help of more than 20 technical personnel, Tian Lu successfully completed his research plan ahead of schedule. And at the suggestion of Professor Bruce, he deliberately left all his articles in

After all the data came out, they were sent to Nature magazine. Fortunately, after receiving Tian Lu’s article, Nature magazine took it seriously and completed the publication in a short period of time.

Completing the predetermined goal is enough for Tian Lu. He does not need to go further. On the one hand, he is indeed tired. He has worked non-stop for so many years. He really needs an unprecedented long vacation. And

On the other hand, some things may not be of more benefit to Tianlu if they go too far ahead...

"Haha, now that we are out, we just want to have fun and relax completely! Don't think about those things, okay?" Seeing that Ye Lan was still a little worried, Tian Lu pinched her little nose and said,

Said with a smile.

When Tian Lu said this, Ye Lan was stunned for a moment, then simply nodded and said no more.

Think about it, on the edge of this desolate desert, what are two people doing with their minds? It's better to think about how to get back to the place where you started...

............................

I posted it very late again. Unlike most people, I am busier than usual on weekends, haha.

Of course, this is the first chapter today, and the other chapter has less than a thousand words written. I’m afraid it won’t be finished before twelve o’clock, but I will go to bed after posting it. You can read it tomorrow morning.
Chapter completed!