Chapter 3374 New specific drugs for treating bacterial infections
So thinking of this, Wu Hao looked at the CEOs present and said with a smile: "After the successful development of this specific drug for Helicobacter pylori infection in the stomach, it also opened up our thinking. Since this super phage can deal with the large intestine
pylori infection in the stomach. So can we use this super phage to cultivate other harmful bacteria that invade the human body?"
After throwing a question to everyone, Wu Hao paused and then answered.
There are many types of diseases caused by bacteria in our daily lives, such as respiratory tract infections.
Bacteria are spread through respiratory droplets or direct contact, and may cause various respiratory infections, such as pneumonia caused by Streptococcus pneumoniae, bronchitis caused by Haemophilus influenzae, and pulmonary tuberculosis caused by Mycobacterium tuberculosis.
There are also urinary tract infections, which are also bacterial infections that we often encounter in our daily lives.
Bacteria enter the bladder through the urethral opening, causing urinary system infections such as cystitis, urethritis, etc. Patients may experience symptoms such as frequent urination, urgency, and painful urination.
Then there are skin and soft tissue infections. Bacteria enter human tissues through skin damage, causing skin and soft tissue infections such as boils, carbuncles, cellulitis, etc.
Finally, there is central nervous system infection. Although this is uncommon, it is very dangerous.
Bacteria enter the brain through blood spread or direct spread, causing central nervous system infections, such as meningitis, brain abscess, etc. Patients may have symptoms such as chills, headache, drowsiness, and lack of consciousness.
In addition to this, there are no bacterial infections in the digestive tract that you will talk about later, such as food poisoning caused by Salmonella, diarrhea caused by Enterobacteriaceae and gastric diseases caused by Helicobacter pylori infection in the stomach, etc.
.
Because your people, including the entire environment, have not yet developed to that point, it is a fact that bacterial resistance has increased. Using more drugs or using more drugs will fundamentally solve the problem.
Having said that, Wu Hao paused for a while, and then continued his sermon.
In addition, the use of antibiotics in small amounts may lead to a few possible consequences. For example, long-term use of antibiotics can stimulate the body to produce antibodies, which may lead to allergic reactions when used again, and may even lead to anaphylactic shock in mild cases.
Wu Hao heard this and replied with a smile: "Actually, it doesn't depend on whether the food is rich. The so-called food can also reduce the number of infected bacteria in the body.
Wu Hao looked around and saw that everyone's expressions were serious and focused, so he continued: "It is very difficult to change the current situation. It cannot be achieved by just a few regulations or widespread publicity.
Secondly, the proliferation ability of super phages is very weak. Under appropriate conditions, super phages can quickly replicate and produce a small number of progeny, thereby achieving inefficient killing of pathogenic bacteria.
For example, your common penicillins, cephalosporins, aminoglycosides, heptacyclines, etc. are all antibiotics.
For example, the super phage that specializes in engulfing Enterobacteriaceae will engulf and destroy other bacteria. The super phage that you have cultivated specifically to engulf Helicobacter pylori in the stomach will also engulf other bacteria.
Speaking of that, Kong Ye paused for a moment, then lowered his tone and said: "The super phage you have developed and cultivated has no natural advantages in the field of treating bacterial infections.
Here, here, long-term use of antibiotics may also lead to seven infections. While antibiotics kill sensitive bacteria, they may also cause sensitive bacteria, usually fungi, to multiply in small numbers, causing new infections.
Therefore, not many experts, including organizations, expressed concern about that situation, or even issued warnings.
That characteristic allows superphages to avoid interfering with abnormal microbial communities during treatment, which may cause side effects during treatment.
If there are fewer bacteria, the super phages will eat less and have sufficient nutrients, so they will naturally unite less. If there are more bacteria capable of growing, they will have more nutrients, and they will naturally unite more.
Therefore, that kind of super phage is very dangerous and will cause harm to the bacteria in its target body.
That’s not alarmist talk, it’s the simple reality you are facing.”
That inefficient killing ability makes superphages have no significant advantage in treating minor bacterial infections. They cannot clear pathogenic bacteria in the body more slowly and shorten the treatment cycle.
However, you know that antibiotics can be abused. In few countries, the use of antibiotics is very tolerant.
After listening to Wu Hao's story, the atmosphere at the scene became solemn. Every boss had a solemn look on his face, and his expressions became serious.
In the past, few minor bacterial infections required long-term degenerative treatment with small amounts of antibiotics, and these were always ineffective.
As for your country, the restrictions in this area are relatively loose. Therefore, this has also led to your increasing sensitivity to antibiotics.
Secondly, excessive use of antibiotics can cause toxic reactions in organs such as the liver and kidneys, damage body functions, and may change tissue structure, increase ototoxicity, nephrotoxicity, and liver toxicity, thereby leading to minor organ damage.
First of all, super phages have extremely weak specificity and can accurately identify and attack specific pathogenic bacteria, but will destroy abnormal bacterial groups.
"What are the appropriate conditions?" Mr. Zhang, who was very curious about knowledge, interjected at that time and asked.
In addition, because the super phage uses bacteria to fight bacteria, any chemical substances present will have toxic side effects on the human body. Therefore, the super phage has almost no side effects, so it can be used by the timid.
What is more likely to be successful is that if you follow the doctor's advice and use antibiotics in sufficient amounts, the antibiotics may not be able to completely kill the bacteria because the antibiotic dose is sufficient. The remaining bacteria will cause the disease to recur and may even lead to drug resistance. That means that in
The same medicine may not work the last time you needed antibiotics.
If there are no bacteria, it means it has lost nutrients and will starve to death."
Therefore, how to solve the problem of bacterial resistance has become a topic of joint research among your domestic experts."
Once you are infected with those bacterial infectious diseases, you must use a small amount of antibiotics for degenerative treatment to kill or inhibit the bacteria.
There are not even very rare bacterial infections, such as cholera, salmonella infection, Lyme disease caused by bacteria of the genus Treponema, gonorrhea caused by Neisseria gonorrhoeae, etc.”
But now we use the kind of super phage that can be cultured, which can replicate and reproduce slowly under appropriate conditions, thereby accelerating the cleaning of bacteria, achieving the goal of inhibiting or even killing bacteria at the slowest speed, and accelerating the recovery of diseases."
Because once bacteria become more resistant to antibiotics, it means that there will be no new antibiotics to kill those bacteria. That also means that diseases infected by those resistant bacteria will be at a point where there are no cures.
