The First Affiliated Hospital of Zhongshan Medical University definitely has the technical capabilities, and there is no need for them to fly there. The doctor who will be responsible for removing the donor heart during the operation later will be Dr. Ye Chuanguang.
"Do your doctors have any requirements for us?" Ye Chuanguang asked.
While Xie Wanying was talking on the phone, she took out the ballpoint pen in her hand.
Seeing this, classmate Wei helped her take out her notebook so that she could write in it.
Xie Wanying wrote down the matters she wanted to coordinate with the other party for Teacher Cheng to review.
Dr. Cheng Yuchen looked at it and nodded.
After getting the teacher's consent, Xie Wanying said: "First of all, the distance to transport the heart is relatively long and the journey takes a long time. Some preparations require your cooperation, Teacher Ye."
"You're welcome." Ye Chuanguang said frankly, "If you didn't call us, we would have wanted to ask you what your plans were. Do you need us to inject the heart from the aortic root and then inject cardioplegia to preserve it?"
"Yes." A great teacher, he understands it almost instantly without saying a word.
"But you must be clear that the cold ischemia time of the heart should not exceed five or six hours." Ye Chuanguang kept reminding him. Don't think that everything will be fine if you take more preparation steps. It will only take a little longer at most.
Cold ischemia can be said to be a proper term in organ transplantation technology. Before talking about cold ischemia, let’s talk about another similar technical term: warm ischemia.
The period of time before the organ is removed from the donor and cold-preserved after the heart has stopped is called warm ischemia. Cold ischemia corresponds to the time period from when the organ leaves the donor to when it is transplanted into the recipient, which mainly refers to the time spent on the road.
Transportation time.
The warm ischemia and cold ischemia time of each organ has an upper limit. For example, the upper limit of warm ischemia and cold ischemia of the heart is the shortest, which are ten minutes and eight hours respectively. The ten minutes and eight hours here are super upper limits.
It's equivalent to a big risk. No one can easily afford this risk. Therefore, Dr. Youye said that the cold ischemia time should not exceed five or six hours. The warm ischemia time of the donor heart in their hospital will be controlled to five
Within minutes.
What happened when the cardioplegia solution was injected? Here again, when the organ was removed from the donor, the cells were not dead but continued to metabolize. Since the blood flow was interrupted and there was no blood nourishment, the removed organ would inevitably consume itself.
Metabolic damage. It is conceivable that warm ischemia will cause the greatest damage to the donor organ during this period. Skilled professional doctors are required to do this to shorten the operation time as much as possible.
How to protect the donor heart during the cold ischemia stage? From a medical technical point of view, it is either the most ideal state, using machinery to simulate the normal human body to continuously perfuse the donor heart, so that the damage is minimal. The problem is that long-distance transportation simply cannot do this.
At this point, we can only retreat and use other methods to reduce the metabolic rate of the donor heart to reduce damage. Therefore, the general organ preservation solution must contain low temperature and other ingredients to inhibit the metabolism of organ cells.
The energy consumption of the heart is mainly composed of the movement of cardiac contraction and relaxation and the metabolism of myocardial cells. The former accounts for 90% of the total consumption. Using cardioplegia can stop the mechanical activity of the heart, and low temperature reduces the metabolism of myocardial cells.
, the combination of the two is equal to one plus one, doubling the effect of reducing losses.
Protecting the myocardium is one thing.
On the other hand, because the heart is not like the liver and has a special structure, the donor heart and recipient require multiple anastomoses.