The research and development of new drugs is an extremely complicated process.
The professional scientific knowledge involved in pathology, pharmacology, medicinal chemistry, clinical medicine, etc. is extremely profound and obscure.
Although Xu Jie obtained the students' unparalleled talents by binding them to each other.
But when it comes to new drug research and development, not just a single subject talent can complete it alone.
Therefore, among the three options given by the system, which one should you choose?
It indeed touches on a blind spot that even Xu Jie has never explored.
However, he didn't worry for long.
If you don’t understand something yourself, you can ask others.
Asking for advice humbly is not something that is difficult for Xu Jie to talk about.
Three people go together there must be my teacher.
Choose the good ones and follow them, choose the bad ones and change them.
Xu Jie found a quieter place in Disneyland and called Expo Yuan.
At this time, the World Expo was far away, not in China, not in Tianjin.
But three days ago, I had flown to Yokohama in the Sakura Country to attend the World Pharmaceutical Science Congress held there.
Shiboyuan can create Boyuan Medicine and make it bigger and stronger. His own strength is very strong.
It's not the kind of pig that manages, cheats on one's background, and takes advantage of the wind to fly into the sky.
Among his own titles are professional certifications such as doctor of chemistry and pharmaceutical expert.
It is a model of successful entrepreneurship for technical talents.
When he received Xu Jie's call, he was quite surprised.
Xu Jie was able to rely on the system and know immediately that Shi Mingyu had won the gold medal in the International Chemistry Olympiad.
But the Expo is far from knowing.
This news has not spread yet.
Therefore, Shi Boyuan himself did not know what Xu Jie was calling him for.
"Hello, Teacher Xu." Shibo said hello to Xu Jie on the phone.
"Hello, Mr. Shi, I would like to ask you a question."
"In the process of developing new drugs, which is the most difficult stage?"
Xu Jie got straight to the point and expressed his doubts.
Expo Yuan, who had just attended a meeting and returned to the hotel to rest, was suddenly stunned.
A middle school teacher.
He is also a head teacher with a background as a physical education teacher.
Actually asked him for advice on new drug research and development?
Even though Shi Boyuan has always had a good impression of Mr. Xu Jiexu, he even regretted meeting him so late during the previous meeting in Jinmen.
But at this time, he was still shocked by Xu Jie's question.
What does the research and development of new drugs have to do with Teacher Xu?
Although Shi Boyuan was extremely surprised, out of his appreciation and trust for Teacher Xu, he still replied with a smile after being stunned for a moment:
"Teacher Xu, I don't know how much you know about new drug research and development."
"Let me briefly tell you some common sense about new drug research and development."
"New drug research and development has always been considered a high-risk, high-yield scientific research."
“In our industry, there used to be a saying about ‘Double Ten’.”
"It means that the research and development of new drugs takes ten years and costs one billion US dollars."
“But in fact, in the actual research and development process, the research and development costs are much higher than this number.”
"Why are many domestic pharmaceutical companies unwilling to do new drug research and development?"
"It's just because it's thankless and the sunk costs are too high."
"It takes ten years to develop a new drug, but it may not be able to be launched on the market and capture the market and make money."
"It's better to pick up people's wisdom and make money by working as a porter or intermediary in the pharmaceutical industry."
"There are only a handful of people in our country who can calm down and spend the cost to develop new drugs."
“New drug research and development is basically monopolized by international pharmaceutical giants.”
"Like Johnson & Johnson, Pfizer, Roche, Novartis, AbbVie, etc."
"Their own accumulation is strong enough, so they can naturally spend more money in the field of new drug research and development."
"Unlike in our country, most people just want to make quick money. They are drunk now and find it difficult to calm down."
Xu Jie was not surprised when he heard Shibo Yuan's words.
There are only a few domestic pharmaceutical companies that can be called giants.
Some are purely Longguo agents of foreign pharmaceutical companies.
Some are alternatives that have grown up relying on the advantages of policies.
Pharmaceutical companies like Boyuan Pharmaceuticals, which have been concentrating on cultivating their internal strength, are also considered to be unique in China.
From the fact that Xu Jie, the head of a family worth hundreds of billions of dollars, was able to send his two sons to Zhenhua Middle School, we can know that he is actually a very affectionate person.
This kind of feeling is not the kind of feeling that people talk about.
Rather, they are willing to work hard in the soil and want to make something earth-shattering.
Xu Jie still admires this very much.
While Xu Jie was thinking, he heard Shi Boyuan continue:
"Generally speaking, the development process of a new drug includes five stages."
“The exploratory stage, the pharmaceutical research stage, the preclinical biological research stage, the clinical research stage and the final post-clinical approval and marketing stage.”
"The first four stages belong to the scientific category."
"The last stage belongs to the political category."
"To say that the most difficult thing among them, from my perspective, there are three points."
"The first point is that everything is difficult at the beginning."
"It is very important to choose which disease to use as the basis for research, how to quickly determine the target, and determine the direction of research and development of a new drug."
"If you start in the wrong direction, years or even decades, billions or even billions will all be wasted."
"Without sufficient scientific theoretical support, throwing money at a mission and moving forward recklessly will not work in the field of new drug research and development."
"This is the main reason why the vast majority of domestic pharmaceutical companies are unwilling to conduct research and development of new drugs."
"Just talking about spending money, in fact, the courage of domestic pharmaceutical companies is not inferior to that of foreign companies."
"But if you drop billions of them, you won't hear the splash of water?"
"With this completely unequal input-output ratio, it is impossible for many pharmaceutical companies to even initiate projects."
Shibo Yuan paused for a moment, letting Xu Jie digest it for a moment, and then continued: ωωw..net
"The second point is non-toxic research."
"Tell me a point of view that you may not understand, Mr. Xu."
“When developing new drugs, the primary consideration is not to cure diseases, but to be non-toxic.”
"The absence of toxicity, or the fact that the toxicity is within a controllable range, is more important than whether it can cure the disease."
"This is the foundation and chassis for new drug research and development."
Xu Jie on the other end of the phone was indeed shocked when he heard this.
The research and development of new drugs is not based on whether they can treat diseases?
But based on safety and non-toxicity?
This statement was indeed far beyond Xu Jie's expectations.
"The third point is to finalize the listing price."
Expo Yuan said again:
"The advent of any new drug must have gone through several years, or even decades, of scientific research and development."
"The human, material and financial resources consumed are far beyond ordinary people's imagination."
"But from the perspective of ordinary people, they only hope to be able to cure diseases with a small amount of money."
"The price was set too high and people reviled it."
"The price was set too low, and the company was unable to recover its capital, and might even go bankrupt."
"This is also one of the reasons why domestic pharmaceutical companies are unwilling to conduct research and development of new drugs."
"You have worked so hard to develop a new drug, and even if it is distributed to patients for free, you will suffer endless criticism."
"Do you want to use our human bodies for experiments?"
"Is the medicine not as effective as advertised?"
"The weaknesses of human nature are easily magnified when people are sick."
After listening to Shibo Yuan's story, Xu Jie felt a chill down his spine in the hot summer.
The research and development of new drugs can be said in just four words.
But the science and human nature involved can be daunting.
"Mr. Shi, thank you."
After a moment of silence, Xu Jie thanked him.
Shibo smiled on the other end of the phone:
"Teacher Xu, you're welcome."
"I don't know why you asked me this question."
"But I am still happy to discuss and communicate with Teacher Xu."
"Whether it is in the company or at home, many people think that I am superior, respect me, and fear me."
"Last time I was in Jinmen, I was able to have an in-depth exchange with Teacher Xu, and I felt the fun that I had not seen for a long time."
Xu Jie laughed dumbly.
It is of course difficult for ordinary people to communicate calmly with the head of a billionaire family.
But Xu Jie has no such worries at all.
When he first guided Shi Mingyu to study hard, he also let Shi Mingyu slap his father, Shi Bo Yuan, in the face with his future achievements.
The two chatted for a while, and then Xu Jie hung up the phone.
At the same time, he had already made a decision in his mind.