Chapter 184: The Tone Killer and the Fetters of Traveling Through Thousands of Years... Right? (6.6K
Qiu Sheng.
He is 186cm tall, weighs 70kg, has thick hair and is handsome.
A Ph.D. in Biology from HKUST and a school scholarship winner is the ultimate template that almost every boy dreams of.
But such a seemingly perfect person has an unspeakable secret that is unknown to everyone:
He has a tone.
According to statistics from Uptodate.
The local incidence of bad breath is about 30%, that is, almost 1 in 3 people suffers from bad breath.
It's just that in most cases, we have smelled it for a long time and have become accustomed to the smell of bad breath, so we don't feel anything at all.
The cause of bad breath is actually very simple. To put it bluntly, there are two common triggers:
20% is attributed to Helicobacter pylori and 80% is attributed to microbial metabolism in the oral cavity.
The latter includes a large number of bacteria such as Neisseria and anaerobic Streptococcus mentioned before.
Actually.
There are many types of bacteria in the human oral cavity, with about 5,600 common species.
There are pathogenic bacteria, non-pathogenic bacteria, opportunistic pathogenic bacteria, etc.
In general...
In every gram of tartar in a normal healthy person, 10 billion bacteria can be found.
With the secretion of saliva, these bacteria will decompose the food residues remaining in the teeth into organic amines, ammonia, sulfides, etc.
It smells like that after long-term accumulation.
Of course.
There is another rare situation:
It means that there is something wrong with a person's rectum, causing the smell of some excrement to flow directly back into the mouth.
This situation does exist, but it must be attributed to the complications of intestinal diseases and does not belong to the concept of bad breath that is usually mentioned.
"Old Xu, the incidence rate of bad breath is 30%!"
In the laboratory.
Qiu Sheng put his hands on the stage and leaned forward, his expression even a little ferocious in excitement:
"Think about how many people there are in the country, not only in the world? If you can apply this new species of microorganisms to clinical practice, your company will be able to walk on two feet!"
As a bad breath patient, Qiu Sheng has tried almost all kinds of treatments on the market.
But whether it’s teeth cleaning, mouthwash, or toothpaste that costs dozens or even hundreds of dollars a piece, the effect is not ideal.
That’s not to say that these are all useless, the key is that their duration is too short.
Take Listerine mouthwash, for example.
This should be one of the more representative brands in oral disinfection at present. Objectively speaking, it does feel okay after rinsing your mouth.
But as time goes by, that taste will reappear in your mouth.
Therefore, the moment he saw the experimental report, Qiu Sheng realized the value of this strain:
Like Bi Chong Lin, the discovery of this strain may not win a high-level award.
But it has unimaginable commercial value!
Compared with Qiu Sheng's excitement, Xu Yun's mood was much calmer. After all, his experiences in his previous life were here:
"Calm down first, Lao Qiu, you haven't even finished your horoscope yet."
"You are also engaged in scientific research, so you should know how difficult it is to move from the laboratory to commercial products."
"Among other things, the cultivation of plants is a big problem. The other is the direction of the finished product. Should it be made into toothpaste, medicine or potion?"
"With different directions, the positioning will be different, and the difficulty will also change."
"So in the final analysis, we still have to take a long-term view. As the saying goes, one breath cannot make a difference."
After hearing what Xu Yun said, Qiu Sheng gradually calmed down.
Actually.
He is not usually an irritable character. After all, he has a very stable temperament when it comes to scientific research.
However, he was an audience member of a new species of microorganism and had been troubled by his tone for too long, so he suddenly lost his composure.
Then he was silent for a moment and asked Xu Yun:
"Old Xu, what are you going to do?"
Xu Yun raised his eyelids and glanced at him, took a picture of his card on the table, pointed at the USTC above and said:
"Of course it's a shaker!"
Half an hour later.
Life Sciences Building.
director's office.
"What? A new type of microorganism?"
Looking at Xu Yun and Qiu Sheng, who looked serious, Tian Zhigang adjusted his black-framed glasses in confusion:
"Why don't you just vote for the new eukaryotic species in "Fuy"? What are you doing here to find me?"
Friends who were microorganisms in their previous lives should know this.
In the biological world, there are actually certain standards for the submission of papers on new species of microorganisms.
For example, Bacteria is submitted to "IJ Color M", the full name is "Iional Journal of Systematid Evolu tiy", and cannot be submitted to other magazines.
The new species of eukaryote is "Fuy", which is an international journal sponsored by the Institute of Plant Science, Chinese Academy of Sciences.
It ranks second among global journals in the field of mycology and ranks third among all 188 SCI journals sponsored by relevant local academic institutions.
Of course.
If you encounter a very valuable new microorganism, it may appear on "pans" as an exception, but it is basically a rare occurrence in several years.
The University of Science and Technology and the Institute of Kunming and Plant Science are both affiliated units of the Chinese Academy of Sciences, so if Xu Yun wants to submit relevant results, he only needs to contact the other party directly.
At least judging from the situation, there was no need to go to the dean's office to inform Tian Zhigang with such a big fanfare.
Looking at Tian Zhigang with a confused look on his face, Xu Yun couldn't help but turn his head and look at Qiu Sheng.
Then he took out a report from his body and handed it to Tian Zhigang:
"Teacher, please take a look at this first."
Tian Zhigang didn't say anything. He took the report and read it:
"A new species of Arthlosporium with a width of 1.5m and an elliptical shape"
The content at the front of the report is mainly graphical data of the new species, which seems to be purely a new type of fungus.
But as my eyes moved downward.
His eyes suddenly became sharper.
A few minutes later.
Tian Zhigang raised his head solemnly and said to Xu Yundu:
"Xiao Xu, is this data accurate?"
Xu Yun nodded heavily and affirmed:
"It's accurate. Before coming here, we collected multiple saliva samples and conducted multiple sets of control experiments."
"In the end, it was found that the disinfecting effect of the new microorganisms was extremely amazing and stable, especially in the saliva sample of a friend of mine, the efficiency was even faster than other ordinary samples."
Qiu Sheng:
""
Tian Zhigang looked at the report again, was silent for a moment, and said:
"If the new species is really what the report says, then its commercial value will be astonishingly high. Xiao Xu, do you have any ideas?"
Xu Yun picked up the teacup and moistened his throat, then pointed at Qiu Sheng:
"Lao Qiu and I had a brief discussion on the way here, and finally we came up with a direction."
Tian Zhigang straightened his body and became interested:
"Oh? Which direction? Mouthwash or spray?"
"No, it's toothpaste."
"toothpaste?"
Tian Zhigang was stunned when he heard this, but he quickly responded:
"A product similar to lysozyme toothpaste?"
Xu Yun nodded and said:
"Yes, it is somewhat similar to lysozyme toothpaste, but it is just an idea at the moment, and further experiments are needed to determine how to operate it."
toothpaste.
This is the prototype of a product discussed by Xu Yun and Qiu Sheng.
The concept of biological toothpaste can be traced back to 20 years ago, but the current development of this field is not rapid.
As of 2022, there is only one most common biological toothpaste on the market:
Plant lysozyme toothpaste.
Plant lysozyme can hydrolyze bacterial cell walls and dissolve a variety of oral bacteria. Plant lysozyme currently on the market is mainly extracted from figs.
But it’s the same as the mouthwash mentioned above.
Although lysozyme toothpaste has a very good disinfection effect in the laboratory, the duration of the practical session is also limited.
If I have to say it, I can only say that it is a little better than enzyme toothpaste, but I am also sorry for its price.
So it can be said.
In the field of toothpaste, there is currently no truly effective biological toothpaste.
This is a huge and empty market.
At the same time, compared with the previous BiChongLin, there is only one barrier in the preparation process of biological toothpaste:
Inactivate.
The so-called inactivation refers to a kind of beneficial bacteria that retains its original structure and characteristics through special inactivation technology, but no longer has the ability to grow and reproduce.
For example, all the probiotic yogurt that everyone drinks uses inactivated bacteria technology.
You can imagine:
If there is a toothpaste on the market that can be used for three months, it can still implant beneficial bacteria in the mouth while cleaning the mouth. This beneficial bacteria will not only disinfect various pathogenic bacteria, but also decompose the bacteria in the gaps between the teeth. Food debris, producing calorie-free metabolites,
Moreover, the taste of this metabolite is very good. You can choose mint flavor, lemon flavor, etc. according to your preference.
In this way, the prospects of this product can be described in three words:
Who else?
Of course.
This is just a prospect idea.
If you want to make new species into finished products, in addition to the barriers in the preparation of finished products, there are also many technical difficulties:
For example, the unit density mentioned before.
Let alone one million units of penicillin, it must be at least 500,000 units.
At the same time, how to ensure the timeliness of the bacterial flora is also a topic that requires careful research:
If you ask someone with bad breath to brush their teeth twice a day, it will definitely be fine. If you ask them to brush their teeth three times a day, they can barely do it.
But what if you have to brush it five or six times, seven or eight times or even more?
Then this kind of toothpaste will lose its actual value.
Think of this.
Tian Zhigang couldn't help but look at Xu Yun and asked:
"Tell me, Xiao Xu, how do you want the courtyard or college to cooperate with you?"
Xu Yun's palms placed under the table were slightly clenched, but on the surface he was still calm:
"The first is the collection of samples. We found that this microorganism will excite green fluorescence when exposed to a wavelength of 365nm, so we hope to collect a full range of bacterial strains from the underground pipes in the school."
Tian Zhigang nodded after hearing this:
"That's no problem. I can apply directly to the school board. It's just a matter of adding a laser inspection to the hardware inspection process. It's not difficult."
Actually.
From the rewards given by Halo, it is easy to see that this new species most likely only exists in the sewer pipe under the basketball court.
However, Tian Zhigang and the others did not know this news. From an outsider's perspective, it was normal to launch a blanket search.
That's why Xu Yun came up with this idea, trying to make his discovery appear more accidental.
Then Tian Zhigang paused and continued:
“In addition to comprehensive testing, what else is there?”
“There is also support in terms of equipment and funding.”
Xu Yun leaned forward slightly and naturally made a request for tickets:
"Theoretically, the new microorganisms have high commercial value, which is exactly in line with the business scope of our Huadun Biotech, so should the school do it?"
Tian Zhigang glanced at Xu Yun and said:
"Isn't that right? There's still a lot of money in the company account, right?"
In the previous financing process, HKUST New Venture Fund, as the leading party, invested a total of 8 million Huaxia coins in cash flow.
The School of Physics and the School of Life Sciences of HKUST each invested two million, for a total of four million.
Xu Yun injected RMB 100 in cash by signing up for HKUST’s entrepreneurial support.
After deducting the rent of 1,314,222 yuan for the factory, the company still has over 10 million yuan on its books.
Facing his teacher's question, Xu Yun scratched his head and said calmly:
"I don't want to save some money. Our company will have a lot of expenses in the future, and all that money is reserved."
"Not to mention anything else, logistics, product costs, and production equipment are all not a small number."
"When the company gets on the right track, we will definitely set up laboratories or even R&D centers and gradually establish our own R&D system."
"But now I haven't sold any cockroach poison. I'm as poor as an Internet writer. You see."
"Go, go, you poor man."
Tian Zhigang waved to him, then pondered for a moment and said:
"Let's see. The hospital just received a few 36-well micro-bioreactors from Japan not long ago. The boxes have not been unpacked. There is also a 350RPM orbital shaker. I will find someone to send it to your laboratory in a while.
.”
"Good guy, are you obsessed with Japan?"
Xu Yun raised his eyelids and looked at his teacher in surprise:
"And a 350RPM orbital shaker? Teacher, when did you become so generous? Don't you have some conspiracy?"
Facing Xu Yun's suspicious gaze, Tian Zhigang's eyes dodge slightly for a few times, and he took a tactical sip of water:
"Don't think too much. There is no conspiracy. I just want you to try a new microfluidic interface nanoliter injection technology and high polymer feeding method."
"This is a new project that Professor Huang Qian's research team in the hospital just completed a week ago. We are just short of a practical report from the laboratory. I thought of you."
"To paraphrase an old friend of mine who is engaged in blasting, Ren Danza, a super blasting expert at the Academy of Engineering, says, it doesn't cost any money, just give it a try."
Xu Yunjian said that the corner of his mouth twitched slightly for a few times, and finally sighed quietly:
"Okay, just do as you say."
It is not an easy task to carry out practical projects for others. Which link succeeds and which link fails, and the data on the failure situation must be collected and summarized.
Like the two technologies mentioned by Tian Zhigang, if practiced alone, including equipment losses, it is basically impossible to make 150,000-200,000 yuan.
Seeing that Xu Yun agreed to his request, Tian Zhigang nodded with satisfaction.
Then I thought of something and took out a fax from the drawer:
"By the way, there was a reply to Dean Hou's patent recommendation yesterday. The patent has been officially approved. The patent number is 20221."
"However, considering that the paper has not yet been published, the patent number has not been announced yet."
"I'll help you inquire about the paper. It will be published in about one to two weeks. After all, it is a manuscript invitation form. Anyway, just wait patiently for a few days."
"By the way, Dean Hou asked me to tell you that this young man has a bright future. Work hard. If you encounter any problems, you can contact him."
"Dean Hou"
Xu Yun took the fax and read several points, silently remembering Hou Xingyuan's favor in his heart.
I may not have enough ability to help Hou Xingyuan at the moment, after all, he is a single-digit boss standing at the top of the Republic's scientific research pyramid.
Their figures went straight into the clouds, and Xu Yun could only look up for the time being.
But with the completion of the Halo mission, he believed that one day he would be able to return this favor to Hou Xingyuan.
Even go one step further and help the country.
This is not conjecture.
Mentioned before.
Before the dungeon mission appeared, Xu Yun's Shirley was about to graduate with a Ph.D., and her ability was probably at the deputy senior level.
At that time, his goal was to follow in the footsteps of Academician Cao Xuetao, the president of Nankai University, and be selected for a senior professional title, that is, a full professor, at the age of 28.
But with the use of the Mavericks experience card, Xu Yun's knowledge of biology has broken through to a whole new level.
The ability is already infinitely close to the high level of popular majors. All that is missing is a professional title selection link.
If there are more rewards similar to thinking cards in the future, Xu Yun firmly believes that it will not take long for him to reach the top of the pyramid.
Then he chatted with Tian Zhigang about other topics and learned about the recent trends and arrangements in the school.
after an hour.
Tian Zhigang received a fax from the school board:
Agree to carry out a scan of groundwater pipes in the school and try to find new and new microbial plants.
The basketball court area was given to Xu Yun, and he was assisted by the school security team who were directly affiliated with the University of Science and Technology and who had accompanied him into Building 14 to collect the cockroach corpses.
ten minutes later.
Xu Yun, Qiu Sheng and Tian Zhigang said goodbye and left the office.
Just when the two of them had just walked out of the medical building, Qiu Sheng suddenly let out a light sigh, pointed in a certain direction and said:
"Lao Xu, look over there."
Xu Yun took advantage of the situation and looked around.
I only see this moment.
There was a group of people gathered under a tree not far away, as if they were watching something, and some were taking pictures with their mobile phones.
Eating melon is an instinct that everyone has, even doctors are no exception. Xu Yun immediately patted Qiu Sheng on the shoulder:
"Come on, let's go take a look!"
In less than two minutes, the two of them reached the edge of the crowd.
As soon as they got close to the crowd, they heard a bunch of chatter in their ears:
"It's so strange, why are there still wild animals running in these days?"
"It's not wild, is it? Our school is in the city center."
"What's going on in the city center? Have you forgotten the wild boar from last year?"
"Wild boars are not a concept that is easy to eradicate. They came down from the mountains and sneaked in during the nationwide lockdown."
"This one probably escaped from some restaurant."
wild animals?
When Xu Yun heard this, a trace of curiosity flashed in his eyes.
Is it a snake or a sheep?
After all, if I remember correctly, there was a snake meat stove near the West District.
At this moment, a boy in front of Xu Yun gave up his seat, so he jumped into the front row.
I only see this moment.
In the center of the crowd stood several security personnel, working together to suppress
A donkey.
Looking at this black donkey, for some reason, Xu Yun suddenly had a strange idea in his mind:
Why does this donkey seem familiar?
Just when he was wondering.
The donkey that was pressed down on the ground suddenly caught a glimpse of Xu Yun's face, and suddenly became excited, and its four hooves struck quickly:
"Oh oh oh oh"
Note:
Someone can actually guess this easter egg, awesome!
By the way, if we do a live broadcast of code words, will anyone come to watch? We won’t show our faces, but we can chat.