Visiting the Key Laboratory of Galaxy Cosmology is undoubtedly an extremely novel experience for everyone in the project team.
Every other line is like a mountain.
This is really not a joke.
Looking at the vast starry sky, the stars are like a curtain, and the whole person will feel a lot more open in an instant.
Come down for a round of stargazing.
Whether it was Xu Yun or the members of the project team, everyone felt a little more relaxed, and they almost shouted that the advantage was mine.
With this motivation and self-confidence, the project team conducted experiments on the second day...
Still failed.
no way.
Scientific research is just like cats, realistically you don’t want it.
It can't be broken through by pouring some chicken soup for the soul and some chicken blood, otherwise humans would have counterattacked to South Gate 2 by now.
It's just that compared to the previous day, everyone's mentality was much more stable.
Don't be emotionally affected by the failure of the project.
What can be met is.
This project is destined to be a time-consuming and labor-intensive tug-of-war, and it will be difficult to see results in a short period of time.
But there is a saying that goes well.
When the east is not bright, the west is bright; when it is dark, the north is bright and the south is bright.
When the Diting project team came to a standstill, good news came from Qiu Sheng:
The laboratory finished product of Yi'anji toothpaste has been successfully produced!
...
The next morning.
4th floor, HKUST Medical Center.
"Lao Qiu."
Looking at the white sticky substance in front of him, Xu Yun couldn't help but have a strong curiosity in his eyes:
"Is this the Yi'anji toothpaste you invented?"
Qiu Sheng on the side had his hands folded in front of his chest with an inscrutable look on his face:
"Of course, if it's fake, we'll guarantee it. If it's fake, we'll compensate you ten percent."
Xu Yun glanced at him and ignored the guy's appearance:
"What you say is unfounded, where is the report?"
Qiu Sheng moved his chin towards Xu Yun's right side with a cold expression on his face:
"There it is, see for yourself."
Xu Yun gave the guy a friendly middle finger, then came to the table, took the report and started reading it.
Seeing that Xu Yun was getting down to business, Qiu Sheng also put down his hands on his chest and explained to Xu Yun while he was reading the report:
"Old Xu, do you still remember that the specifications for our cultivation of Yi'an bacteria have reached 30,000 U per ml?"
"The density is about 50% of that of ordinary probiotic toothpaste. The difference is obvious, but it is far lower than the concept of 'barrier'."
"After that female donkey arrived at HKUST, our supply of donkey hair suddenly increased a lot, and I was able to try various conditions with peace of mind."
"After more than a month, we finally determined the most suitable environment and temperature, and the size of the cultured Yi'an bacteria has reached 70,000 U per ml."
Xu Yun nodded slightly, indicating that he understood.
Mentioned earlier.
In the field of pharmaceuticals and microorganisms, the smallest potency unit with a certain biological efficacy is called a "unit".
Internationally known as IU.
China is called U.
There is no conversion between IU and U, there is only the conversion between IU and weight or the conversion between U and weight.
In other words, the dose level U/L is a unit unique to China.
Generally speaking.
In China, most vitamins are expressed in IU.
Antibiotics are represented by U.
For example, the specifications of penicillin are generally 200,000 U per milliliter, and erythromycin is 70,000 U per milliliter.
Previously, the largest new species unit found by Xu Yun and others in moss was 8000U. The difference of 2000 could exceed 10,000.
Before Xu Yun entered the wheat copy, the specifications of Yi'an bacteria had exceeded 1 ml and 30,000 U.
Now more than a month has passed, and it is not unusual to have exceeded 70,000.
After all, Yi'an bacteria itself is a strain that can survive in difficult environments, and its ability to survive and reproduce is actually very strong.
With an abundant supply of donkey hair and bean dregs, it is only a matter of time to cultivate high-density bacterial strains - simply put, it is a combination.
Then Xu Yun thought for a while and asked Qiu Sheng:
"So Lao Qiu, what about the inactivation process?"
Inactivate.
This is a technique commonly used in a variety of bacteria-containing foods.
This technology does not completely kill bacteria, but uses special means to retain the original structure and characteristics of beneficial bacteria, but makes them no longer have the ability to grow and reproduce.
It looks like castration, but there is still a big difference between it and castration.
If I have to say it...
It is roughly similar to the "erasure of consciousness" of puppets or magic weapons in many fairy novels, and their own bodies are still there.
For example, the probiotics in probiotic yogurt are inactivated strains.
At present, in the field of microbial toothpaste, inactivation is also a very critical technology.
"The inactivation data is on the next page."
Qiu Sheng pointed to the report in Xu Yun's hand, gestured for him to turn the page, and continued to explain:
"Actually, this is what I came to talk to you about today - the inactivation process of Yi'an bacteria is a bit special."
Xu Yun was stunned for a moment, and something suddenly seemed wrong when he looked at Qiu Sheng:
"Special? Don't you need to use some of Brother Donkey's materials? For example, donkey whip?"
"...That's not the case..."
The corner of Qiu Sheng's mouth twitched a few times and he quickly waved his hand:
"It uses the E1cB mechanism."
Xu Yun was stunned:
"E1cB mechanism? This is not a conventional inactivation method, right?"
"So I said it's a bit special."
Qiu Sheng took off his glasses and scratched his auricles, which were a little sore from being pressed by the frames:
"Old Xu, you should know that today's bacterial inactivation is actually a very mature technology, and there are no so-called patents or barriers."
"Most of the time, the inactivation of bacterial cells only requires re-enactment according to certain procedures, which is similar to a formula."
Xu Yun hummed.
Just as Qiu Sheng said.
The current bacterial inactivation technology is very mature and basically only has a few categories:
Inactivation by ultraviolet irradiation, inactivation by high-temperature heating, inactivation by repeated freezing and thawing, formaldehyde, alcohol, and ordinary acid or alkali inactivation.
Just like the formulas in basic mathematics, special situations are rarely encountered in the inactivation process.
"But Yi'an... there's something different about it."
Qiu Sheng put his glasses back on, sighed, and said:
This chapter is not finished yet, please click on the next page to continue reading the exciting content! "The activity of Yi'an bacteria is really too strong. We have used various physical or chemical methods, but the results are not ideal."
"Later I thought about it, and it probably has something to do with the living environment of Yi'an bacteria - that sewer is the main excretion point of HKUST, and all kinds of sweet, salty, sour and spicy food are mixed together, so Yi'an is passively allowed to live.
Antibacteria acquire the property of being less susceptible to denaturation."
"Just like the old folks from Jiangxi, they eat spicy food every day and eventually develop a resistance to spicy food."
"so......."
"In the end, I had no choice but to use a quaternary ammonium base and use the E1cB mechanism to eliminate the hydrogen on the β-carbon of the bacteria, thereby achieving an inactivation effect."
Xu Yun suddenly exclaimed:
"Quaternary ammonium base?"
Quaternary ammonium base.
This is a very special base.
It is at the same level as caustic soda in terms of alkaline strength, but technically it falls far within the category of 'alkali inactivation' as stated above.
When quaternary ammonium bases are heated, a reaction that is opposite to Zaitsev's elimination rule will occur, which is called Hoffmann's rule.
Its essence is a volume effect, which is eliminated from sites with less steric hindrance and is completed through E1cB.
"E1cB..."
Xu Yun touched his chin and asked:
"One step or two steps?"
Qiu Sheng quickly replied:
"In two steps, the acidic proton is removed to form a stable carbanion, and then the lone pair of electrons on the carbon forms a π bond with the adjacent electrophilic carbon, forcing the leaving group to leave."
Do not know why.
After listening to Qiu Sheng's explanation.
Xu Yun suddenly felt a strange feeling in his heart.
It was as if something was floating in front of him, but he couldn't catch it no matter what.
"...."
After a while.
Unable to grasp that thought, Xu Yun could only sigh helplessly and gave up further thoughts.
Strange.
Aren't you very self-disciplined recently? Why do you feel a little mentally exhausted...
Secretly muttering something in his heart that Qiu Sheng could not hear, Xu Yun put the documents away again and said to Qiu Sheng:
"Lao Qiu, how effective is this toothpaste? Can it remove bad breath?"
"Toothpaste works?"
Qiu Sheng barely hesitated and gave Xu Yun a thumbs up:
"Needless to say, it's so good!"
I don't know if it's an illusion.
Xu Yun always felt that when Qiu Sheng said these words, a hint of excitement flashed in his eyes, like rain after a long drought...
However, Qiu Sheng soon noticed something was wrong with him. He coughed lightly and said in a formal manner:
"I...ahem, a friend of mine has used this toothpaste. After using the toothpaste, the number of Neisseria and anaerobic Streptococcus in the oral cavity has dropped sharply to 1% of the original level."
"Without eating, Yi'an Bacteria can suppress the number of two bacteria at 40% of the normal value for 12 hours."
"If the user eats food during this period, the effect of Yi'an bacteria can still last for more than four hours."
"This kind of effect is currently on the market..."
"invincible."
When Xu Yun heard this, his fingers holding the experimental report suddenly tightened.
Pinch out a dent in the report paper.
In the current oral cleaning market, there is only one relatively effective toothpaste:
That is plant lysozyme toothpaste.
Plant lysozyme can hydrolyze bacterial cell walls and dissolve a variety of oral bacteria. Plant lysozyme currently on the market is mainly extracted from figs.
Judging from laboratory data, it can indeed achieve good results.
However, although the plant lysozyme toothpaste has good laboratory data, it is less than satisfactory after commercialization.
Because in principle, there are four elements required for lysozyme to work:
Temperature, sugar, enzyme activity and enough time.
The temperature in the human oral cavity is obviously appropriate, and the enzyme activity will naturally not be too bad through various means.
But sugar and time are big issues.
The little sugar on human teeth is simply not enough for lysozyme to work, and brushing your teeth only lasts for three minutes - some people don't have enough time, so even if you are very capable, lysozyme will still be difficult to work.
If you want to achieve a real deodorizing effect, lysozyme...or enzymes are of little use, and you have to use super-active bacteria such as Eonbacterium.
This is the gap between the laboratory and real-life applications that has been mentioned many times before. The gap between the two situations is too big.
Unfortunately, there are always many manufacturers using laboratory data to deceive people or attract investment. In the end, it is always the consumers who are cheated.
all in all.
Once Huadun Biotechnology's Yi'anji toothpaste is launched on the market, it will be another dimensionality-reducing blow to the bad breath removal market!
"Of course, Lao Xu."
After introducing the effects of Yi'anji toothpaste, Qiu Sheng changed the topic again:
"Currently, what we have completed is still produced in the laboratory. The toothpaste materials only use basic preservatives, friction agents and foaming agents, which are far from reaching the level of commercialization."
"Not to mention that there are currently not enough donkey hairs to cultivate Yi'an bacteria. If this toothpaste is to be officially put into production, it needs to be carefully studied within the company."
"But that area is not my area of expertise. I don't have any suggestions to give you."
Xu Yun nodded seriously:
"I understand, thank you, Lao Qiu."
As we all know.
Toothpaste is a daily necessities for cleaning the oral cavity. Its core main ingredient is actually a friction agent.
most of the time.
The content of abrasives in toothpaste can even exceed 50%.
Common friction agents currently include calcium carbonate, aluminum hydroxide, silica, calcium hydrogen phosphate dihydrate, etc.
Among them, calcium carbonate has sharp crystal particles, which may wear teeth, and has poor compatibility with fluoride, so it is mainly used in low-end toothpaste - such as the toothpaste of some third-rate hotels.
Aluminum hydroxide has a certain relationship with Alzheimer's disease, so in recent years, most companies have stopped using aluminum hydroxide as a toothpaste friction agent.
Therefore, the most common friction agents currently used in the production of toothpaste are generally the latter three.
The three friction agents have different types and prices.
Which materials need to be selected in the product stage requires further analysis.
In addition, there are thickeners, flavors, taste improvers, appearance improvers, acid-base buffers, antioxidants, etc., which all need to be studied separately.
After all, no matter how effective a toothpaste is, it will be uncomfortable to use if it has no taste.
Most of the so-called whitening and sterilizing effects of many toothpastes on the market rely on the psychological implications of the cooling sensation of mint.
Other than that.
The company still needs to obtain some relevant procedures before it can produce toothpaste - but this is not difficult.
When Qiu Sheng began to study the amplification of Yi'an bacteria, Xu Yun and Gu Qunqing had already passed the agreement, and the relevant processes had already begun.
Domestic toothpastes only need product inspection reports and product safety assessment materials, and then obtain the product serial number and national tooth network registration number in the administrative region.
At present, the basic departments of Huadun Biotechnology have been established one after another, and Gu Qunqing has already arranged manpower to submit relevant applications.
As long as the commercialization process is completed, the toothpaste can be on the shelves within a few days.
And the potential market for this toothpaste...
Undoubtedly, it is also an astonishingly large value.
.......
More than half an hour later.
Xu Yun left the laboratory.
As a result, not long after I walked out of the medical center, my cell phone rang.
Xu Yun took it out and found that the note was...
【Mom】.
Xu Yun had fairly frequent contact with his family. He would make a video call or something within a day or two, so he pressed the dial button as usual.
But the next second.
Xu Yun was so excited that he almost threw his phone away:
"Son, mom has introduced you to a girl who lives in Luzhou. When can you go on a blind date?"
