In 2044, Yawgmoth stated that he could not understand why anyone would reject Plan A for HIV infection.
Because whether a person chooses Plan A’s “modified HIV infection” during the “immune system offline” stage, Plan B’s “drugs and radioactive destruction”, or the then-undeveloped “18:3 drug to reverse immune system life”
Cycle", in the second stage of "gene implantation", we have to face the virus cocktail.
The virus cocktail must contain a "prototype" thing with a much higher fatality rate than HIV, that is, rabies (modified version).
Different viruses have different affinities for different cells.
Rabies virus is a neurotropic virus. It has extremely strong nerve affinity. Generally speaking, after rabies enters the body, it can be transported along the reverse axon of the nerves without going through the blood circulation, and violently bombards the brain.
Compared with many viruses in the family Herpesviridae and Picornaviridae, which are both neurotropic viruses, rabies virus has a huge advantage, that is, it is "fast".
It almost specializes in nerves. It can penetrate into the brain as quickly as possible and spread quickly.
The time from onset to death of a patient rarely exceeds 24 hours.
As for the "incubation period", that is, the period "from infection to the discovery of symptoms", it actually only depends on the amount and concentration of the virus received by the infected person.
If a sufficient amount of pathogen is artificially injected, the incubation period can be shortened to a very short time.
What’s more, the incubation period of rabies is inherently very short—the “ten-year incubation period” promoted in the past is more likely to be the result of incomplete records or false alarms, according to the latest research.
It can enter the neuronal system very quickly.
This is exactly the characteristic needed for genetic modification surgery.
Due to differences in metabolism, cells in different parts of the human body renew faster or slower.
And nerve cells are undoubtedly the slowest of them all.
The life span of nerve cells is almost the same as that of the human body itself. They almost never divide, and damage cannot be easily repaired.
This is entirely to ensure the stability of the neural network structure, so the repair function is abandoned.
Its proto-oncogene is quite inactive.
This is why neurons almost never become cancerous.
This characteristic also causes the transformation rate of the nervous system during metal-based surgery to be much slower than that of other parts of the physical body.
The remedy is rabies virus.
Theoretically speaking, this is indeed feasible. Anyway, no matter what the pathogen is, it is powerless to deal with the extremely high body temperature of the baseline human and will eliminate it on its own, so as long as it survives this level, Yawgmoth is guaranteed to be fine.
But here's the problem.
The mortality rate of rabies is also very high, close to 100%.
The blood-brain barrier protects the brain from external infections, but also blocks the entry of most immune cells.
If general immune cells appear near the central nervous system to kill virus-infected cells, then the damage to the neuron network will be greater than that of the virus - the principle of immune cells is to "kill them if they are likely to be infected."
Only some antibodies can enter the brain.
However, a small amount of antibodies and microglia, the "guards" of nerve cells, are not enough to reverse the ravages of the rabies virus.
Once rabies occurs, the mortality rate is close to 100%.
Generally speaking, if you want to avoid death from rabies, you can only produce enough antibodies to suppress the virus before the disease occurs.
But the method proposed by Chen Feng... will undoubtedly make it sick.
After all, this requires simultaneous transformation of neurons throughout the brain.
Since the brain controls all aspects of the body, once the brain is damaged, it is easy to die. The condition for "fatal onset" of rabies is actually "the proportion of infected (destroyed) cells is sufficient to cause death."
This time is still far from "entire brain neurons being infected".
In other words, this is equivalent to asking the person undergoing surgery to live in a "rabies attack" state for several weeks.
On the basis of ensuring the speed of virus transport, it is also necessary to ensure that the virus will not damage the brain's neural network, or "cannot cause death before the transformation is completed", in order to expect that after the transformation is completed, the body temperature of the reference person will spontaneously clear the virus.
This is undoubtedly a difficult task.
But it's not "impossible".
Others in Superman Enterprise obtained Yawgmoth's research records. In order to complete the "virus cocktail" and to give an explanation to investors in HIV research, Yawgmoth made many "reduced power versions" of viruses.
He has a mature method that can be used against most viruses.
Yawgmoth always likes to start from the underlying principles and think deeply.
So, there's only one question left there.
They could only follow that procedure to cultivate the rabies virus with reduced destructive power, but they did not have time to follow the new drug development process and conduct several phases of experiments. As long as it was confirmed that "primate experimental animals can survive for several days after becoming ill,"
They would have to inject Yawgmoth.
They didn't even have time to confirm "whether it would cause irreversible damage to the central nervous system" - at that stage, the "Xiao Huan Dan Project" had only produced signaling factors that could be used in the peripheral nervous system. Huan Dan that could safely act on the central nervous system
Danzyme will not be developed by Yawgmoth for several years.
This kind of thing is gambling on the future. Although there is an excuse of "saving people", this is undoubtedly on the edge of ethics.
If you take it outside, you will easily be attacked.
It's good to succeed, but if it fails, the person who implements the plan will have to bear the burden for a lifetime.
At this time, Niaguti unexpectedly stepped forward to take on this task. Through her connections, she obtained the bat rabies virus, the least destructive of the known rabies viruses. She even excluded most of her assistants from the laboratory
In addition, there are only a few experimenters left - these people have very low positions and are not qualified to "take responsibility".
So does animal testing.
She almost completed the entire process alone.
After finding "an improved virus that would not kill the host immediately after getting sick", he immediately rushed to Yawgmoth.
In the end, she personally injected the virus into Yawgmoth's spine using a subarachnoid injection.
Even if Yawgmoth dies, the responsibility will not affect anyone else.
The end result is quite good.
Although Yawgmoth gained all the glory in the field of biology at that time, Nia Gudi could also be called a "genius scientist".
Yawgmoth survived without any sequelae - the only problem he faced was a few holes in his head.
The nursing team used two methods to ensure the temperature in his cranial cavity. The first was to extract blood from the arteries that supply blood to the brain, cool it outside the body, and then inject it back.
The second is to directly drill a hole in his skull and pass the cooling fluid tube through.