Chapter 282 Doctor Hongs home-made anti-inflammatory medicine
Since Zhao Xin entrusted Lin Ziping with an important task, the old man's body was particularly important.
Historically, after Lin Ziping published "Hai Guo Bing Tan" at his own expense in 1791, it was soon banned by the shogunate. He was also ordered by the shogunate to return to his home in Sendai and "live in seclusion". He died of illness two years later.
So on the next day, after receiving Zhao Xin's order, Sheng Haizhou took Lin Ziping, who had not had breakfast, to the hospital for a physical check-up.
Although Hong Tao hates islanders, he heard that the old man in front of him was the director of the "Surveying and Mapping Bureau" appointed by Zhao Xin, and he also helped Beihai Town draw maps, so he did not dare to neglect it. First, he did a blood test, a urine test, and a stool test, and then X
After the ultrasound and electrocardiogram, Lin Ziping kept complaining.
Afterwards, Sheng Haizhou took Lin Ziping to find Wu Xianhou.
Nowadays, the Wu brothers rely more and more on various examination reports for medical treatment. Although the four diagnostic methods of traditional Chinese medicine have been passed down for more than 2,000 years, this method relies too much on consultation experience and personal cultivation ability; many doctors in this era spend their entire lives
It is difficult to become a general practitioner if you are only good at a certain subject.
Since Beihai Town now has a small number of doctors, what it needs most is generalists who can deal with common diseases, frequently-occurring diseases and general emergencies. Therefore, in the two years since they came to Beihai Town, the Wu brothers have changed from specialist doctors to general practitioners.
What people see most every day are headaches, brain fever and trauma caused by work accidents.
Wu Xianhou took Lin Ziping's various examination reports and read them, and after some consultation and pulse checking, he judged that the other party should have the "upper respiratory tract infection" that Dean Hong had mentioned before.
It is very common these days for wind and cold to turn into pneumonia. Sometimes, even after the fever subsides, the inflammation remains latent, and in the end it results in lung infection or even death.
At that time, Yonglian, the son of Qianlong and Empress Fucha next door, caught a cold and a fever because he went to the northern suburbs to study with them, and finally lost his life.
The ancients' treatment for typhoid fever was either "Guizhi Decoction" or "Ephedra Decoction", which was used to induce sweating and dispel cold, and only rich people could afford it. As for the poor, it would be good if they could just drink a bowl of Coptidis Coptidis Decoction. But even the emperor
My son couldn't be cured, which shows the effect of this thing.
Wu Xianhou has been in Beihai Town for two years. He has seen a lot of the "magic medicine" in Beihai Town and knows how to deal with it. So with a swipe of a pen, he prescribed a "penicillin injection", one injection a day for three days.
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There are currently three types of penicillin powder in Beihai Town Hospital: 800,000 units for people in this time and space, and 1.6 million and 4 million units for people traveling through time and space. The shelf life of this stuff is at most three years, so there is no point in hoarding it if you buy too much.
big.
Although penicillin powder was not expensive in another time and space, after Zhao Xin returned from Guangzhou, he actually asked Hong Tao to take time to develop penicillin.
This time, Hong Tao was stumped. The acetylsalicylic acid mentioned above has not been solved yet. If we try to make synthetic penicillin, it would not cost lives!
Don't talk about boiling willow bark. What's purified from willow bark is called "salicin". From the salicin, a fairly strong organic acid is extracted, which is called salicylic acid. And salicylic acid has a big problem.
, that is, it will irritate the gastrointestinal tract and make it difficult to take. In addition, it is impossible to achieve industrial production simply by extracting it from the bark.
Modern production of salicylic acid is made by reacting phenol with sodium to produce sodium phenolate, and then introducing carbon dioxide under normal pressure to perform a hydroxylation reaction to produce salicylate, which is then acidified with sulfuric acid to produce a crude salicylic acid product.
It is then refined by sublimation to obtain salicylic acid.
Hong Tao has been waiting for almost a year, but the problem of industrial production of salicylic acid has not yet been solved.
The most important thing here is the high-pressure reactor. Zhao Xin can buy one off-the-shelf, but the problem is not to produce it himself. For more than a year, several workers under Zhao Liang have processed more than a dozen of them, and now,
Finally, we were able to build a qualified tank.
The main material of this thing is not complicated. It uses ordinary stainless steel plates. It cannot be made in Beihai Town at the moment, so all the stock is used. However, due to the poor craftsmanship of the workers, the high precision and smoothness of the tank contact surface cannot be guaranteed. In the past few days,
All failed.
During the whole process, Zhao Liang just watched coldly and didn't interfere at all. If he wanted to help, he would definitely do it, but he couldn't do everything!
Several workers who were blacksmiths thought about it for a long time, and finally thought, if we can't make a big one, why can't we make a small one first? So by the time Hong Tao finally saw the finished shell of the reactor, several months had passed.
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Just having a shell is not enough! The kettle lid must also be equipped with a pressure gauge, a vapor-liquid phase valve, a temperature sensor, and a layer of bursting film. In addition, there must be some magnetic coupling, cooling
There are a lot of water jackets.
At this point, all the blacksmiths are completely blind, this is really impossible!
However, being able to make reactor shells means that people in the workshop can already make old-fashioned boilers. At least Zhao Xin no longer has to buy water boilers in public bathhouses and everywhere.
Hong Tao had been thinking about penicillin for a long time but had no idea. The day after Lin Ziping finished his examination, Zhao Xin called.
"Dean Hong, can we get this penicillin?"
"Mr. Zhao, I am studying clinical practice, not biotechnology. Do you want to know how much the wholesale price of 6-APA is now? It is thirty yuan per kilogram. If you buy more, it is cheaper than Chinese cabbage. Let's
There’s no need to bother yourself with this!”
On the phone, Hong Tao explained to Zhao Xin, a half-hearted Mongolian doctor, that there was no need to buy penicillin now.
"As far as I know, there are no manufacturers that synthesize penicillin from scratch for production. They are all semi-synthetic or biological fermentation. Moreover, the synthesis of semi-synthetic penicillin uses 6-aminopenicillanic acid (6-APA) as the raw material.
It can be obtained by connecting various amide side chains using acid chloride method or acid anhydride method. Moreover, the current domestic production capacity is 40,000 tons, most of which are used for export."
"Oh! So that's it." Zhao Xin rolled his eyes and listened to a bunch of terms that he didn't understand at all, and finally heard about overcapacity. No wonder the price is the same as cabbage.
This chapter is not over yet, please click on the next page to continue reading! Didn’t you see how big a stir it was to save a man-made penicillin in "The Good Doctor"? It may not be effective in the end. If it is to be industrialized for medical use, safety must be
is the first.
At this time, Hong Tao continued on the phone: "Mr. Zhao, my opinion is that instead of penicillin, it is better to develop allicin, which is also good for sterilization and anti-inflammatory. And the process is simple and can be used by both humans and animals. Mr. Zhao,
Just let the mycelium go."
How could Zhao Xin know this? He had only heard of allicin before, but he really didn't understand the details. After Hong Tao gave a general introduction to the medicinal effects of allicin, he quickly asked: "Isn't it difficult to make this?"
Hong Tao smiled and said: "Pounding garlic is not difficult. At most, use a stirrer. Solvent or steam distillation is the same as making perfume."
Hong Tao said it was easy, but when he actually made it, he found that it was really troublesome.
The first is that the smell is too great!
It is said that there is no allicin in fresh garlic, only alliin. When the garlic is cut or crushed, the alliinase in the garlic will be activated to catalyze the decomposition and synthesis into allicin.
What’s so outrageous about this thing is that if a brave woman eats garlic before giving birth, the baby’s first cry will be filled with the smell of garlic after birth! That scene, tsk tsk tsk~~
The second is the dose. One kilogram of garlic can only produce up to 8 mg of allicin, so if someone wants to achieve the anti-inflammatory and therapeutic effects of eating garlic, the daily dose must be at least 160 mg.
As mentioned before, allicin can be produced only when garlic is cut or crushed. In other words, you have to eat 20 kilograms of minced garlic. Whether it can cure the disease or not is still a question, but it will definitely die...
.
In the afternoon, Hong Tao and his assistant carried a box of equipment to the big cafeteria in Beihai Town. This thing cannot be made in the hospital, it can smoke out everyone, and some people can even "YUE"...
The first thing is to pound the garlic.
Twenty kilograms of fresh garlic, a dozen women working in the canteen lined up, each had a garlic mortar in front of them, and everyone started pounding, pounding, pounding.
In order to prevent oxidation, after each portion of garlic paste was pounded, Hong Tao's assistant put it into a glass container, sealed it and waited for enzymatic decomposition. After almost one kilogram of garlic paste filled two glass bottles, Hong Tao took action.
In order to make the operation simple and convenient, Hong Tao did not choose to use ethanol for extraction, but used local distillation.
A group of women watched Hong Tao take out a glass distilling bottle and an alcohol lamp from the box. They were wondering what kind of treasure it was. Then they saw Hong Tao, who was wearing gloves and a mask, pour the minced garlic from one of the bottles into the distilling bottle.
In fact, it can be used without a distillation bottle. In ancient times, artificial wine relied on fumigation in a large pot to extract the wine liquid. The principle is the same. Use an iron sheet to make a pot, connect a copper pipe to the lid, wind the copper pipe several times, and use cold water or a wet cloth in the middle to promote condensation.
Just put it on the stove and burn it.
However, temperature is still very important, and the extraction effect is best below 80 degrees.
A few hours later, two bottles of light yellow and clear allicin extracted from 20 kilograms of minced garlic finally came out, and a strong smell of garlic floated in the kitchen operation room.
At this time, the kitchen, including everyone's body, was full of garlic smell. Even the cooks in the cafeteria were so smoked that they came in and went out holding their noses.
When Hong Tao returned to the hospital with two bottles of allicin, he found that everyone who came near him would wrinkle their noses. It was not until he met Director Liu Da that he finally broke out.
"Eh! It stinks so bad. Did you get into the garlic basket?!"
"Ah?" Hong Tao sniffed himself. His nose had already been numbed by garlic.
"Hurry up and take a shower later! Don't come in unless you wash off this smell!" Director Liu walked away, holding his nose.
Hong Tao was stunned for a while, shook his head and smiled bitterly.
Now it’s time to test the effect of the extracted allicin. Who should be the “guinea pig”? This thing is too irritating to the gastrointestinal tract. If you take it directly, you may have a gastric perforation. In other times and places, it is made into capsules and enters
Dissolve after small intestine.
Hong Tao thought for a while, and first went to the injection room to get a bottle of glucose wrapped in plastic, and took a disposable syringe and an infusion needle. Then he changed into clothes and went out, stepping on the snow, and strolled to the horse farm.
Since Liu Zheng went to Guangzhou, the affairs of the racecourse have been entrusted to Yalha. This poor old man now has more than 200 refugees under his command, taking care of thousands of Mongolian horses.
Serdan kept asking him to find another wife, but Yalha always shook his head; the death of his family members at the same time was too irritating to him. Although Yalha looks smiling every day now, the scars in his heart have never been there.
heal.
"Lao Ya, what are you busy with?" Hong Tao opened the door and walked into the racecourse's official room (office), and saw Yalha sitting cross-legged on the fire kang and smoking.
"Hey! Doctor Hong, why are you here?" Yalha looked up and saw Hong Tao. He quickly stood up to greet him and boiled water to make tea for Hong Tao. It was Hong Tao who performed the surgery to remove his fingers and toes.
"Don't be busy, don't be busy, Lao Ya, I came here to ask you if any of the horses in the racecourse were injured?"
Yarha hesitated when he heard the words, and immediately replied: "You really asked, the day before yesterday two stallions started to fuck for some reason, and one of them was bitten."
"Bite through?"
Yarha nodded and said, "It's not broken yet. I asked someone to find some herbs and wrap it up."
Hong Tao was overjoyed and said quickly: "Take me to see it quickly."
Yalha is worried that Dr. Hong has changed his profession to become a veterinarian?
The bitten stallion was kept alone in a pen in a shed, with a droopy head and a listless appearance. The wound at the lower end of the neck was wrapped with a piece of white cloth, and some herbal green liquid oozed faintly.
Hong Tao first asked Yalha to untie the white cloth and then remove the herbs on the paste. Yalha didn't know what he was going to do, but as a doctor, everything he said was right and he had to listen.
During the process of applying the herbal medicine, the horse must have been touched by a wound. It shook its head and neighed in pain, and its hooves jumped uneasily. Yalha calmed down after being comforted for a while.
Hong Tao asked Yalha to lead the horse to the fence and take a closer look. Perhaps the worker assigned by Yalha was not careful in his work, or perhaps there was something wrong with the herbs. The wound had not healed at all and had begun to become inflamed.
When Yarha saw it, he was so angry that he started scolding the worker. The worker had only been at the racecourse for more than a month. He knew that he had done something wrong, but he couldn't help admitting his mistake.
Hong Tao waited until Yalha had finished teaching him a lesson, then he took out the glucose and allicin in his coat pocket and placed them on a wooden board in the stable. He put on gloves and first took 60 mg of allicin with a syringe.
Then inject 500 ml of glucose injection, shake well, and connect the infusion needle.
He had heard Liu Zheng say once before that to give a horse infusion, the needle should be inserted from the jugular groove, which is the long, tendon-like area under the horse's neck. Although the horse's jugular groove is very long, it is only the middle third.
Only one place is safe; the top is too close to the brain, and the bottom is too close to the heart, both of which are inappropriate.
Hong Tao asked Yalha and the worker to calm down the horse. He first reached out and pinched the lower end of the jugular vein. After the blood vessel was exposed, he quickly inserted a needle sideways.
"It's okay! The craftsmanship is intact!" Hong Tao praised himself in his heart.
The horse was also a little confused and shook his head uneasily. Yalha quickly stroked the horse's head to comfort him. After checking that the blood was returning and there was no problem, Hong Tao unscrewed the flow regulator on the infusion tube. This was because it was the first time for the horse to be given blood.
For infusion, Hong Tao couldn't control the flow rate well, so he chose an intermediate flow rate.
After almost forty minutes, the infusion was completed. Hong Tao pulled out the needle and said to Yalha: "Don't apply the medicine yet, just wrap it with a cloth. I'll come over to take a look at noon tomorrow."
After two consecutive days of infusion, the inflammation in the horse's wound was stopped. However, the horse's body emitted a garlic smell mixed with sweat, which could stun Hong Tao.
That’s it! The next step is to detect the allicin content in the extracted allicin solution and improve the extraction rate.
A few days later, Chen Qingsong, who heard the news, immediately issued an order to the civil affairs clerks, informing all residents of Beihai Town and Fuldan City that from now on, every household must grow garlic!