Digitalis and belladonna are the only two natural botanical medicines that are truly confirmed to be effective, and their mechanisms are relatively clear.
The former are fresh plants that have been picked recently; the latter are souvenirs from the trip to Westminster, which have been dried and preserved, and may have a few unpicked blueberries mixed in.
Of course, when they were still fresh and the difference could be seen, Craft had no time to distinguish them carefully. After drying, it can only be said that they are exactly the same thing, almost like strawberry seeds dropped into a pile of white sesame seeds.
Fortunately, there are no accuracy requirements now, and I believe that the sample will not mind whether the reagent has a fruity aroma or not.
Take two teaspoons of dried fruit and soak it in the remaining hot water. The shriveled fruit swells and the liquid is dyed a shiny light purple color, which looks very beautiful in a white glass container with high transparency.
In fact, when belladonna appears at a banquet, it is not always the proud work of assassins, but also becomes a dangerous cosmetic.
Due to the aesthetics that Kraft could not understand, some people insisted that larger pupils would make the eyes appear brighter and more charming. It happened that some wizard discovered that belladonna poisoning can cause pupil dilation.
As a result, belladonna eye drops have become a popular beauty product. Just drop a little before going out and you can have sparkling and charming large pupils. Although there are always accidents with varying consequences, its fans still only grow a lot.
This may be one of the earliest medicinal examples of belladonna, which well explains its pharmacological mechanism, that is, an anticholinergic drug. Since cholinergic receptors are widely distributed in many smooth muscles and glands, belladonna can affect
The scope is very large.
The pupillary sphincter, which controls pupil constriction, is of course one of them. It has to be said that using it topically as eye drops is a relatively wise way to use it - the wisest way is not to use it blindly. "Using blindly" here can express a literal meaning.
Kraft used a quill to absorb a small amount and dropped it on the sample that had returned to normal. The surface without horny protection quickly absorbed the liquid, and the purple color penetrated into the translucent software, slowly spreading and fading.
Following the color diffusion trajectory, you can see some small capillary tubes that are invisible when the color is not developed. The absorbed liquid is transported along with the tube system and quickly penetrates into a corner of the sample, and then stops abruptly.
Following a small but complex fluctuation, the flow of body fluids suddenly got stuck. It was as if the valves in the pipeline closed, forcibly limiting the drug to a certain range, and the diffusion rate was greatly slowed down.
"Is this okay?" The valves in normal blood vessels should function as one-way valves to prevent blood from flowing backward, but in the sample, this simple structure seems to have been modified and can control opening and closing as needed.
You can choose to control the poisoning locally, instead of spreading it throughout the body through blood circulation like people do.
Kraft tried to pour more liquid, but it became "smart" and did not choose to absorb it. Instead, it formed the same cuticle as before to isolate itself from the outside world.
This does not dissuade the professor from continuing the experiment. Since it does not absorb, then inject the drug into it.
He currently does not have a syringe in the strict sense, and has never thought of getting one before. From his perspective, there are basically no drugs suitable for injection.
Unfortunately for patients, the concept of intravenous injections emerged long before drugs suitable for intravenous injections were available.
Some people have long tried to inject drugs into blood vessels to speed up their effects, but of course they are not using syringes. In theory, only a pointed thin tube and a container that can provide pressure can be done.
"Next time I should really ask the Higo family if they can make a syringe. Digitalis will make them agree." Due to limited conditions, Kraft used the ancestor of the syringes provided by the clinic - animals are used to temporarily store liquid metabolic end products.
A skin capsule made from organs.
"Uh, that thing looks a bit like..." Coop felt that there was something wrong with the shape and liquid storage method of this tool.
"You're right. If I ask for it, David won't be able to use it on patients." Kraft connected the needle and balloon, sucked up the belladonna solution, and injected the liquid into the sample.
In order to prevent diffusion difficulties, he deliberately injected at different points and depths in stages.
The sample ball, which was completely dyed lavender, expanded and contracted violently, with a significantly accelerated frequency. However, the digestive vesicles inside became stagnant and sluggish. Some parenchymal particles and small lumps of different colors proliferated and became larger, and there were abundant new blood vessels.
Maintaining their supply is suspected to be the compensatory enlargement of the secretory glands.
As expected, there was another complex fluctuation under the mental sensory field of view, which could not be analyzed. It was probably because the target receptors were everywhere, causing the entire body to adjust.
It took some time for the sample to adjust, and the intensity of the fluctuations was even stronger than when it encountered high temperatures, but it was also more chaotic.
For imbalances in different systems caused by the same drug, it chose to simply use changes in multiple pathways to deal with them.
The assistant noticed that the professor's seriousness was filled with confusion and a little disappointment.
"Purple bell flower stems and leaves are twisted together to make juice, hurry up." He ordered. No one was turning the hourglass anymore, but there seemed to be some other timer urging it.
"Please wait a moment, it will be ready soon." Coop threw the whole plant into the washboard-like juicer, pressed it down to squeeze out the fresh juice, bottled it and handed it to his eager employer.
After a simple four-fold dilution, the digitalis injection was squeezed into the sample that had just calmed down.
Unlike the brightly colored belladonna tea, the light yellow-green solution is difficult to distinguish and impossible to trace after entering it.
Kraft subconsciously widened his eyes and waited for the result. As time passed, the familiar pain and discomfort unexpectedly became less serious. On the contrary, an uneasy feeling of ease grew.
It should be time soon, but physically it wasn't there yet, and he wanted to see it again.
The overall activity of the sample slowed down, but the amplitude became larger, as if it changed from a short gasp to a deep breath, and those rhythmically moving muscle fiber bundles powerfully pulled the surrounding tissue and contracted inward.
The strengthened contraction squeezes the body fluids in the pipeline and pumps them to all parts of the body at high speed, affecting more muscle bundles, so the contraction becomes more powerful.
This chapter is not over yet, please click on the next page to continue reading the exciting content! After this trend reaches a certain limit, the situation is reversed, and the frequency of contraction and contraction begins to accelerate and the intensity becomes weaker.
When the frequency reaches a certain level, the scale of contraction is reduced to an extremely unsatisfactory level. It is more like spasm and trembling than contraction. High-frequency, shallow and fast contraction can no longer effectively generate pressure.
Conditions that occur in humans also appear in samples, manifesting themselves in similar ways.
This could not be more intuitive if used to explain the electrophysiology of cardiomyocytes, and it would be a good teaching aid. Myocardial contraction requires maintaining a certain difference in intracellular and intracellular ion concentration, and the inhibitory effect of digitalis on the sodium-potassium pump must be maintained to a certain extent.
Later, this state will be destroyed due to changes in potassium ion concentration, resulting in a decrease in resting potential.
For those who happen to remember a little bit about the basics of cellular electrophysiology, they will quickly think of what this means - increased excitability.
It manifests itself in the heart, which is getting faster and faster. When it reaches a certain level, like a twitch, its contraction no longer produces effective pressure, just like a hand that is constantly twitching cannot lift anything.
【Ventricular fibrillation】
The most fatal arrhythmia was formed just like that, and the whole process was visualized. The professor looked at Kupp with regret, but it was a pity that the only teachable subject here had not learned it to this extent.
"Let me see, how are you going to deal with it now?" Kraft observed the sample with interest, his attention raised to the extreme.
The entire circulatory system of the sample should have been completely shut down by now, and it would be useless to create any new tissue unless it could reverse this critical problem.
His expectations were answered.
A new wave of waves overflowed from the moon's remains. It may not be very strong, but it was not accompanied by too much clutter, so that it stood out in a brief moment and reached a recognizable level.
The mental organ that is always prepared senses it and burns this ripple that cannot be described in other sensory forms into precise memory.
Visible to the naked eye, the twitching of the myocardial bundle branches in the sample was controlled.