Chapter 254: It takes two Nobel Prizes to complete the task?!
What?
Make vitamin c?
Grete was dumbfounded.
How difficult is it to determine that scurvy is caused by a lack of vitamin C and to do it? Simply put, this achievement is worth two Nobel Prizes.
In 1937, Hungarian biochemist Szent-Gyyi won the Nobel Prize in Physiology or Medicine for his research on vitamin C and oxidation reactions in the human body.
In the same year, British scientist Haworth won the Nobel Prize in Chemistry for determining the chemical structure of vitamin C and artificially producing vitamin C.
Dr. Carlisle, you think so highly of me. If I had the ability to make vitamin C with my bare hands, I wouldn’t have spent more than ten years in my previous life, and I would just be a deputy chief physician!
My highest degree is a master's degree!
My major is clinical medicine, not pharmacy!
By the way, what is the path for industrial production of vitamin C... I have not forgotten this, I have never learned this at all...
Gretel descended to Igor Peak in depression. Thinking of having to climb two Nobel Prizes to complete the task, he felt so weak that he didn't even want to enter the laboratory. In other words, he had to solve a problem that could be solved with one lemon a day.
Is it really good to solve the problem by making a magic potion?
It's so annoying... Why don't you write a paper on the conclusion of lemon juice treatment and send it to the alchemy workshop and let them think of ways to make it into medicine...
Gretel was not happy, so he cast a spell to summon a mount, and he sat on the horse and walked at a leisurely pace. The horse summoned by magic was smarter and more intelligent than the horses that existed in nature. Even if the owner did not control it, it would not be frightened and run around, or
Stepping on people. Gretel was riding a horse in a daze. The horse moved around randomly. Unknowingly, a fishy smell hit his face.
Grete came back to his senses and looked up, only to find that he had walked to the port area. He's here, let's go to the treatment center. With this thought, Grete turned around, click, click, click, soon.
I went around to the treatment center of the Order of the God of Nature.
"Brother Matthew!"
"Hey, little Gretel, why are you here free?"
Pastor Matthew turned his head from the alchemy table and greeted happily. Gretel was a little embarrassed: during this period, he really didn't go to the treatment center much. He was either busy with electrolysis or bacterial culture every day.
After the plague was brought out, people from the religious sect were brought in to help for a while, including treating patients, cultivating, staining, and microscopic examinations. It seems that the council has not calculated the cost of treatment for them... I am really sorry for them...
"Brother Matthew, I'm sorry, I was too busy a while ago." He walked up to the alchemy table and asked, "Brother Matthew, what are you doing?"
"I'm making colchicum tablets... Don't tell me, the colchicine you made is really effective. Those guys with gout last time were cured after just a few days of taking the medicine. Oh, they are quite proud. They have been honest for two months.
He just eats and drinks all he wants, then comes here to buy medicine, and then he starts to mess around again after another two months!"
Colchicine tablets!
Gretel's eyes lit up. He seemed to have grasped an idea, but also seemed not to grasp it. However, now was not the time to be distracted. Gretel rolled up his sleeves and stepped forward to help:
"Brother Matthew, let me help you do it together!"
Weigh, add alcohol, shake, filter, and let stand. Evaporate the alcohol to obtain crude colchicine extract. The content has been calculated last time, so there is no need to calculate it again this time. In short, 20 grams of colchicine powder makes 12
Tablets. Grete was very agile and did the job very smoothly. While doing it, he also reminded Pastor Matthew:
"Brother Matthew, please remember to tell the patient that you can only take 1 to 2 tablets of this medicine every hour, and no more than 12 tablets per day, that is, 24 hours. If you take too much, you will be poisoned! Really, colchicum is poisonous!"
"I know, I know! You told me last time!" Pastor Matthew laughed. "Really, it can be used by cutting a little colchicum powder and kneading some starch, but you have to go through a lot of trouble like this!"
Grete was stunned on the spot.
Yes, that's right. You can just eat medicinal plants directly - or the powder or juice of medicinal plants. Why do you need to make extracts? Why do you need industrial production? Why do you need to use chemical synthesis?
Why do countless researchers in the fields of chemistry, chemical engineering, and biomedicine have to take this path despite all the difficulties and troubles they face?
Not only for monopoly, not only for technical barriers. More importantly, medication safety!
For example, the dosage of colchicine is 0.5 to 1 mg every 1 to 2 hours for adults, and no more than 6 mg per day. If the dosage is too small, it will be useless, and if the dosage is too large, it will be toxic. So, how to ensure the accuracy of the dosage?
?
Control the origin of colchicum? This year's weather, sunshine, precipitation, fertilizer, will colchicum grow well? Only use the bulb, not the leaves, or only use certain parts of the bulb?
This kind of control method may be accurate to 0.1 gram, or 0.01 gram. However, if you want to be accurate to milligrams, or even micrograms, and make the dosage of each medication stable and uniform, you can't do it!
What about drugs with a smaller single dosage? For example, when fentanyl is used for anesthesia induction, the dosage is 0.05~0.1 mg...
Not to mention, there are too many impurities in extracts of medicinal plants. The simplest example is the active ingredient of aspirin, salicylic acid. Everyone knows that willow bark can be obtained by boiling water. However, how much is in willow bark tea?
There are only a few of dozens of them. If you want to extract salicylic acid from it and eliminate the ineffective and harmful ingredients, hehe, you will cry to death.
This is why modern anesthetic medicine only came about after the emergence of modern chemistry. If it were ancient times, henbane, datura, belladonna and other herbs were used, mixed and refined, and then fed to patients, which was a complete gamble on life.
If the ingredients of the raw materials fluctuate slightly, the anesthesia will be excessive and the patient will not wake up...
Only by relying on chemistry and chemical extraction can we measure the content of drugs. Only by chemical synthesis can we make drugs with high purity, uniform and stable properties, and become a reliable helper for doctors!
These principles have all been learned before...
"Brother Matthew, thank you." Grete thanked him sincerely. Before Pastor Matthew could ask, Grete rushed out of the treatment center like a whirlwind and summoned his mount again. He rode around the street twice and stopped.
In front of a fruit stall:
"What's the price of these oranges? Where are the lemons? - I want them all, please help me deliver them!"
A cart of oranges, a basket of lemons, a cart of cabbage, and seven or eight other vegetables were dragged into Grete's villa one after another. The cook wiped her hands on her apron in surprise:
"Mr. Nordmark, are you...are you going to have a banquet?"
*****
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