Eight hundred and seventieth chapters can not tell the secret (a)
"Feifei's mother passed away not long after Feifei was born." Yang Shushan said slowly with a hint of regret.
"Sister Jing mentioned it to me and said it was because of leukemia." Zhang Yang thought to himself, this is not a secret, what the old man wants to say is probably not that simple.
Yang Shushan nodded: "It's leukemia. Jing'er must have told you about it."
"Yeah!" Zhang Yang nodded.
"Feifei's mother has chronic myelogenous leukemia cml." Yang Shushan added.
Zhang Yang frowned slightly. He knew about this disease. Chronic myeloid leukemia is a relatively rare malignant tumor, accounting for about 0.3% of all cancers and 20% of adult leukemias. In the general population, about 1 per 100,000 people.
At least 2 people have this disease, which means that the probability of a normal person getting this disease is about one to two in 100,000, which is very small.
Chronic myelogenous leukemia progresses relatively slowly, so many patients have no symptoms, especially in the early stages. It is not easy to detect. However, if it is discovered, the treatment effect is good, but once it enters the accelerated phase or blast phase, it is more difficult to save it.
Already.
Yang Shushan then said slowly: "When she was diagnosed, Feifei's mother was still in the chronic phase, but the doctor said that it may soon enter the accelerated phase. Merely taking glenin or chemotherapy is of no use. If you want to completely get rid of this disease, you need to
The only way is to do a bone marrow transplant, but Feifei’s mother’s condition is too special.”
Yang Shushan sighed with a sigh: "The doctor concluded that she was hereditary in her family. What's more coincidental is that the chronic myelogenous leukemia she had, after examination, was determined to be a ph chromosome that is generally positive. Instead, it was negative. In chronic myelogenous leukemia, it was found to be generally positive.
Among patients with myeloid leukemia, the proportion is less than 5%. In other words, she should be regarded as a type of accml, and the probability of normal people is only one in millions or even tens of millions."
"Family inheritance...ph chromosome?" Zhang Yang was stunned for a moment. This means that Yang Fei and Yang Jing may also be at risk of inheriting it. For a master of bioengineering, medical and pharmaceutical engineering, Zhang Yang naturally knows about the ph chromosome.
of.
The ph chromosome was discovered by American scientists in 1960 when there was a chromosome smaller than the g group in the blood of chronic myelogenous leukemia. Because ph was first discovered in the United States, it was named the ph chromosome.
The cause of the disease is a translocation of the long arms of chromosomes 9 and 22, which recombines the proto-oncogene abl on the long arm of chromosome 9 (9q34) and the bcr gene on chromosome 22 (22q11) into a fusion gene. This leads to the latter
It has increased tyrosine kinase activity. This is the cause of chronic myelogenous leukemia.
Although this leukemia is also a type of cancer, it is a special type of leukemia, especially one with family genetic factors mixed in, and the ph chromosome is negative. This is almost equivalent to a genetic mutation.
Even Nanxing 1 can only temporarily suppress this disease because the repair cell system in Nanxing 1 cannot completely correct its chromosomes.
A real cure may require allogeneic bone marrow transplantation.
"That's right. Feifei's mother inherited it in her family, and Feifei's grandmother also suffered from the same disease and died after ineffective treatment." Yang Shushan smiled bitterly. "Originally, if chronic myelogenous leukemia is discovered early, there is a chance. Even if it is negative, there is still a chance.
Opportunity through bone marrow transplantation."
Zhang Yang was also aware of this, but Yang Jing didn't explain it in detail at first. Now he knew that the cause of Feifei's mother's disease was so complicated. "Sister Jing also told me that my aunt couldn't find a matching bone marrow at that time."
transplant, so in the end, under the doctor’s advice, I gave birth to Teacher Feifei again, but..."
"However, Feifei still couldn't match her mother. In the end, she could only watch her transition from the chronic phase to the accelerated phase, and then died soon after." Yang Shushan sighed and said, "Actually, when Feifei was six years old,
, went for a check-up, and found that the cells in her body also had the ph chromosome."
"What? Are you saying that Teacher Feifei also has leukemia?" Zhang Yang couldn't help but trembled when he heard this.
Yang Shushan nodded, but immediately shook his head: "Feifei is fine. The presence of ph chromosome does not mean leukemia, but it is an important cause of leukemia."
"It's just that when our whole family was worried, she didn't show any abnormality in her body. This continued for six years. When she was twelve years old, she went for a check-up and found strangely that the ph chromosome had disappeared and her ph chromosome had disappeared.
No other abnormalities were found in the blood."
"Oh!" Hearing this, Zhang Yang couldn't help but breathed a sigh of relief. Although if Yang Fei really got that disease, he would save her even if he had to consume all the system points. But getting that disease would do too much harm to her after all.
He always hoped that Yang Fei would be safe and well.
But when he looked at Yang Shushan's face, he still seemed to have a sad look on his face. Could it be that there is still a problem?
"Is there anything else you haven't said yet?" After all, Yang Fei was involved, so he just blurted it out.
"Yeah!" Yang Shushan nodded, "Just when we thought there was nothing wrong with Feifei, when she was seventeen years old, her grandmother passed away and the family was in a mess. That year, she happened to be admitted to Mening University, and we started again
During her physical examination, it was discovered that she had the ph chromosome again, and what’s even more terrible is that she somehow knew that she was actually born to save her mother.”
"Since then, the gap between her and Xiu Guo has become deeper and deeper." Yang Shushan's face showed a hint of deep pain, "But this is nothing. What we are more worried about is her health. The doctor told us,
She probably inherited her mother's genes to have this condition, but Feifei's ph chromosome disappeared inexplicably for a while. Medical experts and genetic experts told us that this was probably due to Feifei's own immune function self-repair.
Already."
"However, her ph chromosome appeared again, which made us very worried. However, in this case, we did not dare to tell her, so we could only contact Mei University secretly. Through them, we could monitor her physical condition at any time. Fortunately,
, from her freshman year to her senior year, she didn’t show any abnormality, and by the time she was in the first year of graduate school..."
Yang Shushan took a breath and paused.
"How was your first year of graduate school?" Although Zhang Yang knew that everything was fine, he still couldn't help but worry about Yang Fei.
"During the first research, the ph chromosome suddenly disappeared again." Yang Shushan shook his head and said with a confused expression, "We don't know why, but as long as her body is fine, it is more important than anything else."
"Yeah!" Zhang Yang nodded. Generally speaking, in Yang Fei's case, her body's immune function comes into play. Generally speaking, when human cells detect chromosomal damage, the cell cycle check point will be automatically activated.
, generally there are two checkpoints: g1/s and g2/m. The atm protein will respond to DNA double-strand damage, and the atr protein will respond to DNA single-strand damage. Both activate the downstream DNA repair pathway, which will cause damage to DNA.
DNA damage is repaired.
In Yang Fei's case, it should be that her DNA repair pathway was turned on and the damaged chromosomes were automatically repaired. But the strange thing is that since it had been repaired before, how could it happen again?
Is it the genetic code of their family's recessive genes that is more powerful, or is it her body's self-immune repair ability that is stronger?
Zhang Yang looked at Yang Shushan and asked, "So, has Teacher Feifei found any abnormalities in her body in the past few years?"
"No, but I'm worried whether this will happen to her again. After all, I'm still worried after what happened last time. I've asked the experts why Feifei has a ph chromosome, and there are rare cases.
The negative pH is most likely caused by family inherited genes, which means that it is very likely to reappear, and as age increases, the possibility of mutation will become higher and higher."
"Since you have decided to be with Feifei now, I think it is necessary for me to tell you about her situation so that you can be mentally prepared." Yang Shushan looked at Zhang Yang and asked, "Are you confident? In fact... you still regret it now.
It’s too late.”
"Even if the universe returns to the singularity, I will still hold Teacher Feifei's hand." Zhang Yang stared at the night sky that was like a piece of sunglasses. Although there were not many stars, the crescent moon seemed to look brighter at the moment.
Exceptionally bright.
Just like the faint halo derived from Yang Fei's extremely beautiful face.
"What's more, don't forget, I am the boss of Nuwa Group. Even if the teacher does have any problems in the future, I believe I have the ability to handle it."
"As long as you say this." Yang Shushan nodded with satisfaction, "I believe you will be able to protect Feifei."
"Don't worry, I won't let her suffer any injustice."
"There's one more thing I just told you." Yang Shushan looked around to make sure there was no one there, then whispered in Zhang Yang's ear, "It's the life experience of Feifei's mother."
"Teacher Feifei's mother? I heard Sister Jing say that isn't she a rich girl?"
"This is just one of the identities." Yang Shushan whispered, "Even she herself may not know that her mother is actually from Jingshuixuan."
"You...you always know about Jingshui Xuan?"
"How could I not know that the ancestors of the Yang family were royal physicians. Even in modern times, the Yang family is still a leader in medicine. The successive owners of Jingshui Xuan have a very close relationship with the Yang family."
"So Feifei's grandmother is...could she be the current owner of Jingshui Xuan?"
"Haha, of course not, but she has a great relationship with the current owner of Jingshui Xuan. If we want to count, the current owner of Jingshui Xuan is Feifei's grandma and aunt. Feifei's mother and she are cousins.