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Since our army in Shandong captured Tianjin, occupied Qingdao and Jinan twice, and seized a large number of various industrial equipment, the pharmaceutical factory of the Logistics Command of the Shandong Military Region, located deep in the Taiyi Mountains, has complete facilities and abundant talents, including a Western Medicine Department and a Traditional Chinese Medicine Department.
, the materials department, manufacturing department, laboratory, warehouse and other departments, in addition to producing penicillin, an extremely precious drug, can also produce more than 40 kinds of injections and tablets.
and more than 20 types of pills, powders, ointments, elixirs and other Chinese patent medicines as well as alcohol, baking soda, cotton wool, gauze, etc. In addition to meeting the needs of our army in Shandong, we are also responsible for providing medical supplies to our army in northern Jiangsu, southern Hebei, and central Hebei.
mission. In particular, the cowpox vaccine successfully developed by Xinhua Pharmaceutical Factory was inoculated to children in the Shandong base area, which relieved the pain of smallpox in children and was well received by the people in the base area.
After Liu Yimin arrived at the pharmaceutical factory, he listened to reports from the director of the pharmaceutical factory, Li Weizhen, and the political commissar Liu Renbao. When he heard that the pharmaceutical factory's pharmacist Cheng Wenzang and chemist Hu Jiamo, under the guidance of Chen Tonghe and American doctors, were developing inactivated cholera vaccines and plague reduction vaccines.
When the vaccine was developed, Liu Yimin was very excited. At that time, he called Cheng Wenzang and Hu Jiamo and asked them to introduce the development situation in detail.
Cheng Wenzang reported that scientists had isolated Vibrio cholerae as early as 1883, and immediately began to develop a non-oral inactivated cholera vaccine. In 1884, clinical trials were conducted in cholera-affected areas in Spain, and the incidence rate in the vaccinated group was significantly reduced. By the Second World War
ten
In the 1990s, when a large-scale cholera epidemic broke out in India, inactivated cholera vaccine was used on a large scale, with an effective rate of 80%. Our army seized a small amount of vaccine in Tianjin, Jinan, and Qingdao. The pharmaceutical factory is currently trial-producing it through experimental analysis and is in the process of cultivating the pathogen.
proliferation stage.
As for the live attenuated plague vaccine, Cheng Wenzang said that it had been used abroad in 1908. However, due to frequent wars in our army, pharmaceutical factories often interrupted production and were unable to develop it. Now that plague has appeared in the base area, they have begun to develop it.
Only then did Liu Yimin realize that he was not good at studying. Before time travel, he read the information at a glance. He always thought that streptomycin had not appeared at this time and that the plague vaccine would not appear. In fact, such a thing already existed.
Liu Yimin's time was precious, so he led a few people to the laboratory and checked it out. He felt that the steps for developing a cholera fire-extinguishing vaccine were consistent with what he remembered. As long as they were inactivated and purified, the pathogen could completely lose its infectivity.
Almost all the components of the pathogen are retained to produce an inactivated cholera vaccine with better epidemic prevention properties.
Because he had experience in guiding the development of penicillin, Liu Yimin was confident in the successful development of streptomycin. However, he was not a medical student. The reason why he was able to guide the development of penicillin was because penicillin was so famous and there was a lot of information on the Internet for later generations.
Streptomycin is not only a specific drug for the treatment of plague, but also a specific drug for the treatment of tuberculosis.
There is a lot of information on the Internet about effective medicines, but there is definitely not as much information as about penicillin. Moreover, in order to conceal his identity as a time traveler, he could not directly tell the process of industrial production of streptomycin in later generations. He could only lead Cheng Wenzang and Hu Jiamo
Let’s start with the pathological analysis of Yersinia pestis, and then try to extract Streptomyces, step by step.
After pathological analysis of Yersinia pestis, penicillin was used to conduct a sterilization experiment. In this experiment, Cheng Wenzang and Hu Jiamo discovered that the principle of penicillin sterilization is to "attack" the cell wall of the bacteria, causing it to be defective, thereby causing the bacteria to lose its protective barrier and then rupture and die.
But the special thing about Yersinia pestis is that in addition to the protection of the cell wall, there is also a capsule composed of polysaccharides on its periphery, which is like covering the Yersinia pestis with a layer of armor. In this way, using
Penicillin is ineffective against Yersinia pestis.
Liu Yimin expressed his idea, which is to develop an antibiotic with similar properties to penicillin. The target is the ribosome of the plague bacterium. The role of this organelle in bacteria is a protein processing plant, which is necessary for bacterial growth and reproduction.
All proteins are produced by this processing plant. After this antibiotic takes over and destroys the processing plant, the germs are like venomous snakes that have been strangled seven inches, and they have no other choice but to die obediently.
The most important thing when doing anything is to have the right idea.
You should know that Waxman, the inventor of streptomycin, discovered Streptomyces as early as 1915 when he was in college. At this time, he was leading dozens of students in the laboratory to study how to isolate less toxic Streptomyces.
New species!
Strictly speaking, Liu Yimin's approach is a very unethical plagiarism. However, in order to fight the Japanese, it is not a bad idea to borrow the wisdom and hard work of the predecessors. In the words of later generations, it is like using a golden finger!
All the technical staff of the pharmaceutical factory were mobilized. Under the guidance of Liu Yimin, Streptomyces was successfully discovered from soil microorganisms. After nearly a month of hard work, Streptomyces was successfully isolated from the soil and chicken throats.
A Streptomyces strain that can inhibit Mycobacterium tuberculosis. The new antibiotic Streptomycin was secretly born at the Pharmaceutical Factory of the Logistics Department of the Eighth Route Army Shandong Military Region.
Liu Yimin couldn't restrain his joy and couldn't wait to instruct Cheng Wenzang and Hu Jiamo to extract streptomycin from the nutrient solution using the activated carbon adsorption method, the dissolution method, and the precipitation method, and ordered people to rush to the field hospital for clinical trials.
Liu Yimin locked himself in the laboratory of a pharmaceutical factory to guide the manufacture of streptomycin. Shun Tada was not idle in Peiping. The Japanese army kept dropping Yersinia pestis in various places in Shandong. The Eighth Route Army was unable to guard against it.
The Japanese plane dropped again
Sao. In more than a month, the plague spread in Shandong, and every household in a village was wiped out. Although the troops were better, more and more people were infected with the plague, and the camp was full of injuries. Luo Ronghuan, who was in charge of the work
Chen Tong, who was in charge of epidemic prevention, was so worried that his head was pounding.
Perhaps feeling that the struggle was over and the Eighth Route Army's combat effectiveness must have dropped significantly, Jun Tada once again mobilized troops to attack Jiaoji Road.
This time, Tada Shun learned the lesson well. He used the North China Security Army as the main force. One Japanese division commanded a North China Security Army group, and he also centralized the second and third tank divisions. Once again, a formation was formed.
steel torrent,
Starting from Zhangqiu, they attacked eastward. Luo Ronghuan and Cai Zhong commanded the troops to fight and retreat, fighting step by step. The Japanese army reoccupied Jiaoji Road. The 11th Division took over the defense of the original 32nd Division and restored
The situation of heavy troops besieging central and southern Shandong.
Luo Ronghuan and Cai Zhong sent several telegrams a day to inform Liu Yimin about the Japanese army's reoccupation of Jiaoji Road, so he naturally knew about it. However, the Japanese army's reoccupation of Jiaoji Road itself was within Liu Yimin's expectation, and he had already made up his mind to seize the Jiaoji Road in Shandong Province. Determined to eliminate as many elite Japanese troops as possible and lay the foundation for the northward march into the Northeast, he did not care at all about the Japanese army reoccupying Jiaoji Road. Only then did he calm down and immerse himself in guiding the pharmaceutical factory to develop streptomycin.
As soon as the streptomycin from the pharmaceutical factory arrived, Chen Tong used it on the soldiers infected with the plague. This use really had immediate results. Fortunately, Chen Tong directly sent a telegram to Liu Yimin, saying that the new drug was symptomatic and effective. Obviously, it is recommended that the commander orders the pharmaceutical factory to produce at full capacity!
At this time, Liu Yimin put his heart into his stomach and simply stopped doing nothing. He sat in the pharmaceutical factory and guided the development of cholera vaccine and attenuated plague vaccine.
We waited until December, when it started to snow heavily, and two vaccines were successfully developed. Liu Yimin was the first to receive the vaccine, and notified reporters from Dazhong Daily to rush to the pharmaceutical factory and take photos of him receiving the vaccine for publicity. Encourage fellow villagers in the base area to actively get vaccinated.
With streptomycin and vaccines, Liu Yimin was no longer afraid of the little devils fighting germ warfare, so Liu Yimin rushed back to Dadian Eighth Route Army Shandong Military Region Headquarters with confidence.
As soon as Luo Ronghuan saw him, he said that there were major changes in personnel within the Japanese army, including Prince Kanin Miya Zaihito, Lieutenant General Sawada Shigeru, Deputy Chief of Staff, Major General Tominaga Kyouji, Chief of Operations, Lieutenant General Ando Tokiyoshi, Commander of the South China Front, and Nakamura, Commander of the 5th Division. All Akito were dismissed, suspected to be related to the Japanese occupation of Vietnam. Sugiyama veteran Japanese became the chief of staff, Lieutenant General Tsukada became the deputy chief of staff, Major General Tanaka Shinichi, the chief of staff of the Army in Mongolia, became the chief of operations, and Lieutenant General Harem Jun He was appointed commander of the South China Front, and Lieutenant General Matsui Tairo was appointed commander of the 5th Division.
Liu Yimin said as soon as he heard this: "On the surface, it seems that the Japanese army's fifth division is attacking northern Vietnam with force, which violates the original intention of the Japanese army to peacefully enter Vietnam negotiated by the Japanese government and the French Vichy government. In fact, it is because the Japanese army is rushing to deploy southward." Operations in Southeast Asia. Emperor Hirohito was afraid that if the war went unfavorably, Prince Kanin Miyazaihito would be brought to trial in the future, so he protected him and removed him from office. The old devil, Mr. Shansugi, didn't know whether to live or die, and regarded the hot potato as a hot potato. It seems that Shun Tada is really an idiot marshal!"
When Cai Zhong heard this, he said: "That's right! It should be said that Terauchi Juichi, Sugimoto, and Tada Shun had fought so many defeats, let alone being dismissed, just saying they were shot several times was normal. But Emperor Hirohito was a bastard, and he actually If we don’t remove them from their posts, all of them will still be playing tricks on the stage!”
Luo Ronghuan then reviewed and said that the defensive operations of Jiaoji Road were not performed well, which allowed the Japanese army to reoccupy Jiaoji Road, which greatly reduced the results of the Shandong War. Moreover, due to the large-scale bacterial warfare of the Japanese army, the combat effectiveness of the troops was reduced and casualties were caused. If it increases, it will be impossible to regain combat effectiveness without a few months of rest and replenishment.
Liu Yimin said with a smile: "There is no need to review this. No one would have thought that the Japanese army would continue to carry out germ warfare on a large scale. However, we are no longer afraid of it. With streptomycin and vaccines, germ warfare by the little devils will have no effect. Moreover, we There are also retaliatory measures. Didn’t Li Lingfeng and the others go to the home base of the Japanese Army’s bacteria unit? Next, it’s Tada Shun’s turn to cry!”
Cai Zhong then reported that the New Fourth Army had won the Battle of Huangqiao and eliminated the main force of Han Deqin. Now, Chiang Kai-shek was angry and ordered the New Fourth Army to move north. The central government was having a verbal war with Chiang Kai-shek!
Liu Yimin became anxious when he heard this, and hurriedly asked Cai Zhong to get all the telegrams from the central government and the headquarters during this period. He wanted to read them.
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