Section 124 The Dilemma of the Pharmaceutical Factory
Chapter 124 The Dilemma of the Pharmaceutical Factory
Just think about the subtropical climate, jungles, and water network terrain. Shi Niaoren believes that more than half of the world's pathogens can be found in this ghost place. His mentor in the United States will definitely have a soft spot for this place. It's a pity that he was not deceived at the time.
Come on. This old man is as strong as an ox, but he is a good worker for the Ministry of Health. At least he can be used to test poop.
Looking at the pile of poop sample jars in front of him, Shi Niaoren's heart was filled with grief and anger that others could hardly imagine - he was naturally sent here to deal with poop as a big beast.
To make matters worse, Shi Niaoren found that the infection rate began to increase. He detected more than ten kinds of parasite eggs from asymptomatic people, such as Clonorchis sinensis and Taenia solium. There may be more bacterial carriers, but because of bacterial testing,
The complexity of the disease is much greater, and many are still undiagnosable. In short, no one realizes the complexity of modern medical testing.
The ignorance and indifference of ordinary people who traveled through various parasites and infectious diseases gave him even more headaches. Those who ate wild fruits indiscriminately, hunted in private, and had sex with local women...
Reporting to the Executive Committee, I always have no specific response measures, but I don't pay attention to it at all!
Maybe an infectious disease pandemic would make Mr. Wen and Ma Du Gong sober up? Shi Niaoren put the petri dish under the microscope and looked at it carefully.
Fortunately, there was neither Arcobacter cholera nor other bacteria causing serious infectious diseases in the sample. However, a large number of Salmonella was detected. Overall, it seems that this unlucky guy has acute enteritis. Theoretically speaking, generally
Acute enteritis can be cured by ensuring that the patient is not dehydrated, has no electrolyte imbalance, and takes simple antidiarrheal drugs.
"If there were some antidiarrheal medicine in the quarantine camp, coupled with some saline water, this person would not have died." Shi Niao Ren felt a little regretful. As long as there were belladonna tablets and a few bottles of normal saline, he could be relieved.
Then he thought that the weather was getting hotter and gastrointestinal diseases were more common, so he had to immediately look for cheap and easy-to-get antidiarrheal drugs. Suddenly he thought of the opium in the warehouse of the Ministry of Health. He had been leaving it in the warehouse after buying it from Macau. Although opium is a drug,
But it has a strong effect on relieving pain, cough and diarrhea. It is a universal medicine that is urgently needed now.
Shi Niaoren disposed of the specimens, washed his hands, lit a cigarette, and called Wu De to tell him that the yellow disease warning in the quarantine camp could be lifted. Then he called Wu Nanhai to ask him to pay attention.
Hygiene issues in canteens and food processing plants.
"...Tomorrow," Shi Niaoren looked at the schedule, "I will come to inspect it personally and help you with some summer hygiene precautions."
"Okay, welcome." Wu Nanhai's voice sounded a little nervous on the phone.
"Don't be nervous, I'm not the Health Bureau here to fine you." Shi Niaoren said, "Don't do a surprise cleaning, let me see the real situation, so that I can prescribe the right medicine. Why don't you apply powder with donkey dung and eggs instead?"
If there is no problem, something big will happen in the future.”
After taking care of Wu Nanhai's health check, Shi Niaoren wanted to make another call to the pharmaceutical factory, but then he thought that he might as well go there himself and take a breather on the way - he had been up since 5 o'clock in the morning to smell poop, and it was already almost noon
When you go to the pharmaceutical factory, you can also stop by the farm for a meal.
The pharmaceutical equipment factory is located inside the farm. It is a composite reinforced concrete frame building. A chimney is spitting smoke into the air. It is equipped with a dedicated boiler room, ground energy air conditioning, self-purified water source and a dedicated garbage incinerator.
The overall infrastructure is of first-class quality. However, this is Shi Niaoren’s first time here after the pharmaceutical factory was completed and put into operation - after all, he is not in this profession.
The pharmaceutical equipment factory is a first-class unit with strict access control. The iron-clad gate of the yard is tightly closed. He rang the doorbell for a long time before a face appeared through the small window on the door - Shi Niaoren was shocked. This
It's a burned face.
Then he remembered that this was a disabled soldier. These people now basically work as janitors in key departments.
"Dean!" The guard quickly opened the door as soon as he saw that he was the dean of the hospital and the director of the factory.
Although Shi Niaoren had the impression that he had treated this person, he could not remember his name. He just nodded politely: "Is Zhao Yanmei here?"
"Yes, yes," the doorman responded repeatedly, "You go to the office and sit down first, I will inform -"
"No need, I'll find her myself wherever she is."
"Director Zhao said," the guard thought for a moment, "No one else can come in while she is working. I'd better inform her."
The room prefixed with 0 indicates that it is in the basement. It is probably a bacteria laboratory. Although Shi Niaoren is not engaged in biochemistry, she knows a little about the principle - she is probably doing things like bacterial culture and does not want people to come in and bring in miscellaneous bacteria.
.
"How did you notify me?" Shi Niaoren became curious. Although there is a phone here, there is no internal phone.
"Use this." The guard limped and led him into the guard room. There was a shelf along the wall, divided into several rows, with small nameplates nailed to them. On the nameplate was a small bell and a pull rope.
.
The guard carefully wrote the date and visitor's name in the registration book with crooked handwriting, and then pulled the rope under a certain nameplate a few times. After a while, the small bell on the nameplate also rang.
"Director Zhao knows. She will come out immediately."
"? This system is good." Shi Niaoren thought to himself that this is similar to the electric bell in the inpatient department of the hospital. Although it cannot communicate, it can at least convey simple information. I wonder if this system can also be used in hospitals. Later
I need to ask Zhao Yanmei to find out.
Zhao Yanmei's office was separate, and Shi Niaoren sat there for a while before seeing her come back.
It turned out that Zhao Yanmei was inoculating kasugamycin in the strain laboratory. This antibiotic is mainly used in agriculture to prevent crop diseases and has little medical value - it is used to treat mild infections that are not serious. Shi Niaoren was a little dissatisfied -
―In his opinion, if it is jointly organized with the Committee of Agriculture, it will have such a result. Their needs must be met first.
Zhao Yanmei saw the leader's expression was not very lively and guessed what he was thinking.
"This is also a practice!" She explained, "Cultivation of kasugamycin by local methods is relatively simple and does not require high environmental conditions. If this can be done, it will be easy to cultivate other strains later."
Shi Niaoren hurriedly asked: "What kind of bacteria are we going to cultivate next? Can penicillin work?"
"Cultivation of penicillin is not difficult, but purification is troublesome." Zhao Yanmei frowned, "When the conditions are better, you can culture oxytetracycline first. This is relatively simple."
It's also good to use oxytetracycline, which is almost as effective as tetracycline and is a fairly broad-spectrum antibiotic.
"It's good to have oxytetracycline." Shi Niaoren's face looked much better.
Zhao Yanmei's next words made Shi Niaoren very unhappy again: "It's also good for fattening pigs."
"Fattening pigs?"
"Yes, this is what Lao Yang said." Lao Yang is naturally Yang Guigui.
"I'm afraid that by then there won't be enough medicine for people. Now we are short of antibiotics!" Shi Niaoren said with a distressed expression.
"No matter how urgent we are," Zhao Yanmei said, "the antibiotics we create have not been tested on animals. The antibiotics produced under our conditions will have impurities. I'm afraid something will happen to people if they eat them..."
"We can't worry about so much now," Shi Niaoren said, "solve the problem of existence and non-existence first."
Zhao Yanmei came from a regular pharmaceutical factory, but she was still not used to the idea of making do with simple things and implementing local methods. She was a little speechless for a while.
"It's not that important, right?" Zhao Yanmei said, "The acid and alkali plant will be put into operation soon. After it is put into operation, the coal chemical combined plant will also be put into operation. It will be fine once it is put into operation."
"I saw it in the newspaper." Shi Niaoren was not interested in coal chemical companies. "There are many coal chemical products, probably synthetic ammonia? But they are all used in industry. Can antibiotics be produced?"
"Sulfonamide!" Zhao Yanmei said, "Ji Situi said that once this coal chemical complex plant is put into operation, the by-product will be sulfonamide raw materials."
Of course Shi Niaoren knew what sulfonamides meant. This chemical compound was first discovered in dyes and was the most effective anti-infective drug before penicillin antibiotics. In this time and space where bacteria have not yet developed drug resistance, this chemical compound alone
It can save countless lives!
"Really?!" Shi Niaoren was so surprised and happy that he almost stood up. This was great news.
"Ji Situi is right. He is an expert, so he won't talk nonsense."
"Well, well, this matter needs to be followed up! Follow up!"
"Don't worry, the acid and alkali plant won't be ignited until the day after tomorrow, and the coal chemical plant will have to wait for a while. According to Ji Situi, they haven't even shipped enough coal."
"Okay, let's not talk about it for now." Shi Niaoren remembered that his main business was not to find antibiotics. He told Zhao Yanmei about the current health conditions and suggested that pharmaceutical companies should make some commonly used drugs in the near future.
"...antidiarrheal medicine, normal saline, glucose solution, and bleaching powder."
Zhao Yanmei said: "To be honest, the only things that can be delivered immediately are distilled water for injection, a dozen kinds of Chinese patent medicines, physiological saline, and alcohol. Even making glucose is difficult..."
"There are still problems with normal saline," she continued. "The salt sodium chloride shipped from the First Salt Farm Village is not pure enough and has too many impurities. Secondly, there is not enough sulfuric acid. We don't dare to make normal saline for infusion. We need to get some oral solution first.
Bar."
"If you want anything else, I'll apply to the Planning Commission again!"
"There are too many things required. I'm afraid the Planning Commission can't do anything about it - Committee Member Ma doesn't have the ability to make things out of nothing." Zhao Yanmei smiled bitterly, "Doctor Shi, you should know that modern pharmacy is actually chemistry."
"You mean-" Shi Niaoren understood what she meant, "There are not enough chemicals?"
"Not only is it not enough, it is simply lacking. Let's talk about the glucose rehydration solution you want. The glucose process is very simple. It is easy to make starch with the acidification method. But I don't have acid: neither hydrochloric acid nor sulfuric acid, so I have to use enzymes.
The chemical method is time-consuming and labor-intensive, and the pH value of the produced glucose cannot be corrected - there is no alkali."
Shi Niaoren nodded.
"Also, gauze, absorbent cotton. As usual, you need to degrease first - you need caustic soda. But the caustic soda is in short supply now. There are not enough disinfectants available, and the products produced can only be said to be makeshift. Fortunately, large-scale trauma
Not much." She stopped talking, "At present, apart from bacterial culture and proprietary Chinese medicines, pharmaceutical factories really can't produce anything particularly effective."
"Don't worry, these will be solved in the next few days, and Bopu's chemical plant will be put into operation soon. I told the planning committee to let the pharmaceutical factory get priority." Shi Niaoren encouraged her.
"That's good. With three acids and two caustic soda, many things can be made." She stood up and took out a piece of paper from the drawer of her desk. "These are some things that need coordination and urgently needed supplies."
Shi Niaoren took it over and took a look, and there were many items listed on it: the machinery department was required to provide a knitting machine with special specifications to weave gauze; a full set of cutting equipment and workers who knew how to cut - this was used to make masks.
; Various oversized pots, earthen pots, iron pots... The glass factory has the most order requirements: a large number of utensils, pipes and alcohol blowtorches.
"There are also small injection bottles." Zhao Yanmei said, "This thing is difficult to make, and the glass factory may not be interested. The Planning Commission must directly issue a research and development order."
"Are you going to make an injection, oxytetracycline injection?"
"We will make traditional Chinese medicine injections for the time being. We are going to make some injections of honeysuckle and isatis root, as well as cardiotonic drugs - it should be possible to extract atropine."
"This thing -" Shi Niaoren still had some impressions of the deaths caused by traditional Chinese medicine injections back then, "is it safe or not?"
"It's not safe enough. The ingredients of traditional Chinese medicine extracts are mixed, and the pharmacological principles are not clear enough. However, traditional Chinese medicine injections such as honeysuckle, isatis root and Shuanghuanglian have been used for decades, and the mortality rate is acceptable. They are not very dangerous.
As for atropine, it is a very dangerous thing. But atropine is an important rescue medicine and very useful, so we should try it first."
"Okay." Shi Niaoren knew that this was a helpless move.
"I have another request." Zhao Yanmei continued, "It is best to keep all the empty bottles used in the hospital, such as injection bottles, infusion bottles, and medicine bottles, and hand them over to the pharmaceutical factory. We can reuse them."
These things are all kept. According to the regulations of the Planning Commission, no modern products can be thrown away casually. Even those that are not used temporarily must be stored in advance.
"I'm keeping these. And they've all been cleaned and disinfected. But they're all in the Planning Committee's account. I'll talk to the Planning Committee and approve them for you together."
"I have one more request -" Zhao Yanmei probably felt that her request was a bit excessive, "Can you give us an X-ray machine?"
Shi Niaoren was startled.
What does the pharmaceutical company want with this thing?