Tanglou did not hesitate at all and told Professor Liu about his plan to develop high blood pressure drugs.

After hearing Tanglou's ideas, Professor Liu was obviously a little surprised. He stared at Tanglou carefully and said, "Tanglou, your subject is a bit big."

In his tone, it was obvious that he did not believe that Tanglou could complete such a grand project with its current capabilities.

"Professor Liu, of course I know how complicated the process of new drug research and development is, but I still want to give it a try."

The purpose of Tanglou coming to Professor Liu was to develop new drugs. Of course, he could not change his original intention, and he could not tell Professor Liu that he already had the technology to develop new drugs.

Seeing Tanglou's persistence, Professor Liu smiled helplessly and said, "Tanglou, I can tell you responsibly that if your proposal is so grand, even if I pass it, the college will not be able to do it in the end.

You may be allowed to pass. After all, developing new drugs is not developing a new dish. There are too many things involved, and it requires sufficient financial support."

Of course Professor Liu is telling the truth. If he hadn't known about Tang Lou's talent, any other student who dared to set a topic like this would have been kicked out by Professor Liu. It's too unrealistic.

Professor Liu thought for a while and said to Tanglou: "In this case, I will give you another week to think about whether to change the topic. If you insist on trying, it is not necessarily impossible, but you have to find a way on your own.

Experimental funding to solve this problem, or some way to get those pharmaceutical companies to invest in your research and development."

Professor Liu is very clear about the process of new drug research and development: "I am not trying to hit you. I will wait until you can complete the basic research, clarify the pharmacology and lead compounds, and then talk about the next details. Of course, the most important thing is that you have enough

Financial support, otherwise everything will be a castle in the air.”

Tanglou thought for a while: "Okay, Professor Liu, I will give you an answer in a week."

"Okay, let's get here today. I still have a meeting to hold. Tanglou, you can go to the department this week, or you can focus on your proposal report first. If you have any questions, you can contact Liu Qiqi."

After Liu Juzi took care of them for a while, she asked Tang Lou and Liu Qiqi to leave her office.

Seeing Tanglou's back, Liu Juzi rubbed the bridge of his nose and sighed in his heart: This boy is really a little different from ordinary people.

Liu Qiqi didn't say a word all the way out, but just walked with the tenement building.

It wasn't until she said goodbye to Tanglou that Liu Qiqi slightly frowned and sighed, hoping that this junior fellow apprentice would be able to retreat despite the difficulties.

After bidding farewell to Professor Liu and Liu Qiqi, Tanglou returned directly to his dormitory. The dormitory for doctoral students in Zijingang Hospital is a single room, so it is very quiet for a person.

Tanglou directly entered the system space and opened the drug research and development laboratory for the first time.

The drug research and development laboratory in the system is no different from an ordinary research institute laboratory. The only difference is that the raw materials and instruments in the laboratory are all virtual. Tanglou only needs a thought to obtain the relevant raw materials.

Instruments can appear, and Tanglou tried it. In the laboratory, various chemical reactions and processes can be simulated at double speed.

Under the technology of research and development of anti-hypertensive drug CCB, countless knowledge appeared in Tanglou's mind. CCB is calcium ion antagonist.

There are several names of drugs in it: nifedipine controlled-release tablets, nifedipine extended-release tablets, nifedipine tablets, amlodipine besylate tablets, levamlodipine besylate tablets, felodipine extended-release

Tablets, benidipine tablets...

Since it is still only one-star level, it can only develop one of them. After looking at the introductions of several drugs, Tanglou chose one of the felodipine sustained-release tablets as the first drug to be developed this time.

After choosing Tanglou, the introduction of Felodipine Sustained Release Tablets appeared:

[Drug name: Felodipine sustained-release tablets, a calcium channel blocker, used for hypertension and stable angina pectoris

Ingredients: The main ingredient of this product is felodipine.

Pharmaceutical properties: Felodipine sustained-release tablets: film-coated tablets, which appear white or off-white after the film coating is removed.

Specifications: Felodipine sustained-release tablets: 2.5mg, 5mg

Usage and Dosage: Oral, dosage should be individualized.

The medicine should be taken in the morning with water. The tablets should not be broken, crushed or chewed.

1. Treatment of hypertension: It is recommended to use 5 mg once a day as the initial treatment dose, and the common maintenance dose is 5 or 10 mg once a day. The dose can be reduced or increased according to the patient's response, or other antihypertensive drugs can be added. Dosage

The adjustment interval is generally not less than 2 weeks. For some patients, such as elderly patients and patients with liver damage, 2.5 mg once a day may be sufficient. Doses exceeding 10 mg once a day are usually not required.

2. Treatment of angina pectoris: It is recommended to start with 5 mg once a day, and the usual maintenance dose is 5 or 10 mg once a day.

3. Renal function impairment: Renal function impairment does not affect the plasma concentration of felodipine. No dosage adjustment is required. Patients with severe renal function impairment should use this product with caution.

Clinical Application and Guidelines: Drug R&D Technology Level Is Not Enough

Adverse reactions: laboratory testing is required to verify

Contraindications: Drug R&D level is not high enough

Note: Drug R&D level is not enough

Pharmacological effects: The level of drug research and development is not enough

Toxicological effects: The level of drug development is not high enough

】

After reading it, Tanglou was speechless for a while. Sure enough, drug research and development is not an easy task. He has already cheated, and there are still a lot of unknown problems.

Tanglou looked at the main ingredients of felodipine sustained-release tablets and checked them again:

[Felodipine: Felodipine; 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxyethylmethyl ester;

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

Physical parameters: Density: 1.277g/cm3

Melting point:142-145℃

Boiling point: 471.5°Hg

Flash point:239°C

Vapor pressure: 4.62E-09mmHg at 25°C】

After reading it, Tanglou felt dizzy. If he had studied it by himself, he would probably not be able to find this compound alone for more than ten years.

Fortunately, with one-star level drug research and development skills, Tanglou has mastered all separation and purification methods such as fractionation, crystallization, and various chromatography techniques.

It was in the system laboratory that Tanglou began to try to prepare samples of felodipine.

Chemical equations and various preparation methods appeared in my mind one after another, and countless chemical steps began to be sorted out automatically.

As soon as Tanglou thought, various reagents and tools appeared on the laboratory table.

"Double speed!"

In front of Tanglou, the process that originally took several days was shortened to a few seconds.

"Fractional distillation, double speed!"

"Crystalization, double speed!"

...

Tanglou was completely immersed in preparing samples of felodipine. In order to prepare samples in reality, Tanglou had to simulate all operations until he was completely proficient.

After a long time, Tanglou finally mastered the synthesis route of the entire compound and found the fastest way from among many ways.

And in the virtual laboratory, the main physical parameters were quickly measured at double the speed.

After several attempts, Tanglou was already very familiar with the synthesis route of felodipine and tried to synthesize it once at normal speed.

In the virtual laboratory, various instruments and reagents continued to appear in Tang Lou's hands. With Tang Lou's concentration, a small tube of felodipine finally appeared completely in Tang Lou's hands.

Looking at the small dose of reagent in his hand, Tanglou was very excited.
Chapter completed!